Sjögren's syndrome at the crossroad of polyautoimmunity
| Autor: | Alberto Rodriguez-Rodriguez, Rubén D. Mantilla, Juan-Manuel Anaya, Jorge Cárdenas-Roldán, Mayra R. Guarin, Adriana Rojas-Villarraga, Liliana López Kleine, Juan Arbelaez, Ricardo Pineda-Tamayo, Manuel J. Amador-Patarroyo |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Thyroiditis Autoimmune thyroiditis Cross-sectional study Comorbidity Abortion Logistic regression Autoimmune hepatitis Inflammatory bowel disease Arthritis Rheumatoid Cigarette smoking Pregnancy Risk Factors Antiphospholipid syndrome Autoimmune disease Prevalence Immunology and Allergy Lupus Erythematosus Systemic Middle aged Priority journal Smoking Middle Aged Enteritis Sjogren's Syndrome Sjogren's syndrome Rheumatoid arthritis Cross-sectional studies Systemic sclerosis Regression Analysis Sjögren's syndrome Female Regression analysis Human Vasculitis Adult medicine.medical_specialty rheumatoid Immunology Vitiligo Major clinical study Inflammatory bowel diseases Article Multiple sclerosis Systemic lupus erythematosus Internal medicine medicine Psoriasis Humans spontaneous Disease duration Spontaneous abortion Autoantibodies Lupus erythematosus business.industry Arthritis Autoantibody Thyroiditis Autoimmune autoimmune systemic medicine.disease Inflammatory Bowel Diseases Polyautoimmunity Abortion Spontaneous Cross-Sectional Studies Risk factors Multiple autoimmune syndrome Pernicious anemia Risk factor business Sjoegren syndrome |
| Zdroj: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| ISSN: | 1095-9157 |
| Popis: | The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases. © 2012 Elsevier Ltd. |
| Databáze: | OpenAIRE |
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