Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples
| Autor: | Wu Zhong, Zhihong Wu, Yingmei Feng, Jie Ma, Yunping Zhu, Danlei Mou, Ling Leng, Luye Lv, Zhongjie Hu, Hongjun Li, Feng Gong, Jiang Zhao, Shikun Zhang, Wei Li, Ruiyuan Cao, Yan Dai, Haiping Xiang, Lei Zhao, Bintao Qiu, Dunqin Gao |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Proteomics 0301 basic medicine Cancer Research Proteome Angiogenesis lcsh:Medicine Severe Acute Respiratory Syndrome Bioinformatics Severity of Illness Index Pathogenesis 0302 clinical medicine Lung lcsh:QH301-705.5 NF-kappa B Lung Injury medicine.anatomical_structure 030220 oncology & carcinogenesis Infectious diseases Cytokines Female Autopsy Infection Coronavirus Infections Metabolic Networks and Pathways Signal Transduction Pneumonia Viral Article Betacoronavirus 03 medical and health sciences Immune system medicine Genetics Humans Pandemics Aged SARS-CoV-2 business.industry Gene Expression Profiling lcsh:R COVID-19 Molecular Sequence Annotation medicine.disease respiratory tract diseases Gene expression profiling Pneumonia Gene Ontology 030104 developmental biology Gene Expression Regulation lcsh:Biology (General) business |
| Zdroj: | Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-9 (2020) Signal Transduction and Targeted Therapy |
| ISSN: | 2059-3635 |
| DOI: | 10.1038/s41392-020-00355-9 |
| Popis: | The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were upregulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. |
| Databáze: | OpenAIRE |
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