Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxidative stress model
| Autor: | Masanori Hosokawa, Masaaki Sakura, Ayako Furukawa, Noriko Kawamura, Masanao Niwa, Yoichi Chiba, Minoru Takeuchi, Emi Kamiya |
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| Rok vydání: | 2012 |
| Předmět: |
Senescence
Pathology medicine.medical_specialty Interleukin-1beta Gene Expression Nitric Oxide Synthase Type II Dermatology Matrix metalloproteinase Biology medicine.disease_cause Thiobarbituric Acid Reactive Substances Biochemistry Proinflammatory cytokine Skin Aging Transforming Growth Factor beta1 Interferon-gamma Mice Downregulation and upregulation Matrix Metalloproteinase 12 medicine Animals RNA Messenger Molecular Biology Lipid peroxide Interleukin-6 Tumor Necrosis Factor-alpha Cell biology Hairless Oxidative Stress Phenotype Matrix Metalloproteinase 7 Models Animal Oxidative stress |
| Zdroj: | Experimental Dermatology. 22:62-64 |
| ISSN: | 0906-6705 |
| DOI: | 10.1111/exd.12059 |
| Popis: | Skin photoageing is a complex, multifactorial process and both intrinsic and extrinsic factors may contribute to its pathogenesis. The ultraviolet-irradiated hairless mouse has been used as an animal model for photoageing, but this model mimics only the 'extrinsic' aspects. Here, we show that skin from old SAMP1 mice, a model for higher oxidative stress and senescence acceleration, exhibited histological and gene expression changes similar to those in human photoaged skin without ultraviolet irradiation. These changes include an increase in elastic fibre and glycosaminoglycan histologically, an upregulation of several proinflammatory cytokines and matrix metalloproteinases, and an increase in lipid peroxide. We propose that SAMP1 mice are a spontaneous animal model for photoageing caused by an exaggerated intrinsic mechanism, namely, higher oxidative status. This mouse model is useful to explore the link between oxidative stress and photoageing, and to evaluate the efficacy of antioxidants. |
| Databáze: | OpenAIRE |
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