Peak post-transplant lung function in bilateral lung transplant recipients using a prediction model based on donor and recipient demographic characteristics
Autor: | Daniel Gutteridge, David W. Roe, Michella Azar, Sheila Krishnan, Chadi A. Hage, Timothy E. Stump |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Single Center Pulmonary function testing Young Adult 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Internal medicine medicine Humans Lung transplantation Restrictive lung disease 030212 general & internal medicine Lung Demography medicine.diagnostic_test business.industry Middle Aged respiratory system medicine.disease Tissue Donors Transplant Recipients Obstructive lung disease Respiratory Function Tests respiratory tract diseases medicine.anatomical_structure 030228 respiratory system Cardiology Female business Lung Transplantation |
Zdroj: | Respiratory Medicine. 155:29-35 |
ISSN: | 0954-6111 |
Popis: | Rationale There are no reliable methods to predict lung function following lung transplantation. We sought to devise a prediction model of peak pulmonary function testing (PFT) post-transplant based on donor and recipient demographic characteristics. Methods Single center retrospective analysis of bilateral lung transplant recipients between 2011 and 2015 without evidence of allograft dysfunction in the first year was performed. Peak PFT post-transplant was determined by serially measured FEV1 and FVC. Using the NHANES III equation, donor demographic characteristics were used to calculate predicted lung function. Multivariable linear regression helped determine which donor and recipient characteristics affected peak lung function and identify the discrepancy between donor predicted and recipient observed PFT post-transplant. Results 146 donor/recipient patients were analyzed. 80 had obstructive lung disease, 66 had restrictive disease. Peak post-transplant FEV1 and FVC was reached in 64.30 ± 48.96 and 78.14 ± 50.68 weeks, respectively. Spirometry values peaked earlier in restrictive lung disease recipients. Higher peak FEV1 was significantly associated with younger donor age, non-African American donor race, male recipient sex, greater recipient height, underlying obstructive lung disease. Greater absolute differences between donor predicted and observed FEV1 were significantly associated with male donor sex, greater donor height, non-African-American donor race, female recipient sex, greater recipient height. Conclusions Donor and recipient characteristics can help predict lung function post-transplant. Patients without complications in the first year post-transplant may take greater than one year to achieve peak lung function. Such predictions can help guide clinical decision making in the right setting. |
Databáze: | OpenAIRE |
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