Distribution of 99mTc-labeled lymphocytes in control and inflamed rats
| Autor: | Paolo Gerundini, Fabio Riccardo Colombo, Attilio Bondanza, Elisabetta Ferrero, Massimo Gasparini, Alessandro Fulgenzi, Rosangela Casati, Maria Elena Ferrero |
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| Přispěvatelé: | Fulgenzi, A, Casati, R, Colombo, Fr, Gasparini, M, Ferrero, E, Bondanza, Attilio, Gerundini, P, Ferrero, Me |
| Rok vydání: | 2004 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Metabolic Clearance Rate Inflammation Technetium Tc 99m Exametazime In vivo medicine Animals Tissue Distribution Radiology Nuclear Medicine and imaging Lymphocytes Radionuclide Imaging Lymphocyte homing receptor Total blood Chemistry Rats Inbred Strains Molecular biology Rats Inbred F344 Rats body regions Organ Specificity Molecular Medicine Radiopharmaceuticals medicine.symptom CD8 Homing (hematopoietic) |
| Zdroj: | Nuclear Medicine and Biology. 31:631-638 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/j.nucmedbio.2004.01.004 |
| Popis: | We studied the in vivo fate of CD8 + lymphocytes, of naive (CD8 + CD45RC bright ) or memory (CD8 + CD45RC dim ) phenotype, injected in syngeneic rats, after their sorting and labeling with [ 99m Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8 + lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats. |
| Databáze: | OpenAIRE |
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