Association between Sarcopenia and Dipstick Proteinuria in the Elderly Population: The Korea National Health and Nutrition Examination Surveys 2009–2011
| Autor: | Du-na Hwang, Minyong Choi, Sang Hyun Lee, Young-Min Park, M. W. Cho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Sarcopenia National Health and Nutrition Examination Survey 030232 urology & nephrology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine 030212 general & internal medicine Intensive care medicine Proteinuria business.industry Odds ratio medicine.disease Obesity female genital diseases and pregnancy complications Chronic Renal Insufficiency Original Article medicine.symptom Metabolic syndrome Family Practice business Kidney disease |
| Zdroj: | Korean Journal of Family Medicine |
| ISSN: | 2092-6715 2005-6443 |
| Popis: | Background Sarcopenia and proteinuria are significant health difficulties in the elderly; however, few studies have investigated their relationship. In this study, we investigated the association between sarcopenia and proteinuria in Korean subjects over 60 years old. Methods We included data from the Korean National Health and Nutrition Examination Survey, a cross-sectional, nationally representative survey conducted from 2009 to 2011 (n=4,008). Sarcopenia was defined using appendicular skeletal muscle mass as a percentage of body weight. Proteinuria was defined by a urine dipstick test result above trace levels. Results The overall proteinuria prevalence was 7.2%. The incidence of sarcopenia was significantly higher in subjects with proteinuria. The prevalence of proteinuria was significantly higher in the sarcopenic group (5.5% vs. 14.5% in the non-chronic kidney disease (CKD) group; 17.2% vs. 23.2% in the CKD group) than in the non-sarcopenic group. Furthermore, sarcopenic participants had worse metabolic parameters, such as higher body mass indexes, waist circumferences, and fasting glucose levels, and lower high-density lipoprotein cholesterol levels than those in the non-CKD group. After adjustment for confounders, the odds ratios (95% confidence interval) for proteinuria were 2.84 (1.92-4.18) in the sarcopenic non-CKD group, 3.70 (2.59-5.30) in the non-sarcopenic CKD group, and 5.19 (2.64-10.18) in the sarcopenic CKD group, compared to the non-sarcopenic, non-CKD group. Sarcopenia increased the proteinuria risk in elderly participants without CKD, even after adjustment for obesity, hypertension, diabetes, and metabolic syndrome. Conclusion These findings showed that sarcopenia was associated with dipstick proteinuria, especially in elderly participants without CKD, regardless of comorbidities. |
| Databáze: | OpenAIRE |
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