Asymmetries in the spatial distributions of enhancing lesions and black holes in relapsing-remitting MS
| Autor: | Anne C. Feng, Hans-Peter Adams, Simone Wagner, David F. Sobel, James A. Koziol |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Lesion Multiple Sclerosis Relapsing-Remitting Double-Blind Method Physiology (medical) medicine Humans medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Radiography Neurology Relapsing remitting Homogeneous Cladribine Functional significance Female Surgery Neurology (clinical) Radiology medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Journal of Clinical Neuroscience. 12:895-901 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2004.11.010 |
| Popis: | Magnetic resonance imaging (MRI) is the most important paraclinical test in the diagnosis of multiple sclerosis (MS) and for delineating its natural history. We investigate MRIs from a longitudinal study of 24 relapsing-remitting MS patients who had monthly MRI examinations for one year, and were not receiving active MS therapy during this period. We hypothesized that lesions occur randomly throughout the brain, and that patients are homogeneous with regard to spatial patterns of lesion presentation. We recorded the numbers and locations of enhancing lesions and hypointense lesions (black holes) in all scans, and found asymmetrical patterns of lesions about the mid-transaxial, mid-coronal, and mid-sagittal planes. Furthermore, in distinct subsets of patients, enhancing lesions and black holes tend to occur in the same locations. Clustering in lesion locations may be of functional significance, with consequent therapeutic implications. |
| Databáze: | OpenAIRE |
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