Morphometry and epidermal fas expression of unexposed aged versus young skin
| Autor: | Nayera H. Moftah, Nagwa H Abd El-Aal, Mohamed S El-Hakeem, Abdalla Y El-Shaal, Neven B Hassan, Faten A Abd El-Wadood |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty H&E stain Dermatology Masson's trichrome stain chemistry.chemical_compound medicine lcsh:Dermatology Orcein Fas aging Epidermis (botany) integumentary system business.industry lcsh:RL1-803 elastic fibres Intrinsic and extrinsic aging medicine.anatomical_structure Basic Research chemistry collagen fibres immunohistochemistry Immunohistochemistry business Immunostaining Elastic fiber morphometry |
| Zdroj: | Indian Journal of Dermatology Indian Journal of Dermatology, Vol 57, Iss 3, Pp 181-186 (2012) |
| ISSN: | 1998-3611 |
| Popis: | Background: Identifying the molecular mechanisms of intrinsic aging is critical in developing modalities for reversal of cutaneous aging. Objective: The objective was to evaluate the expression of epidermal Fas, epidermal thickness, collagen, and elastic fibers degeneration in unexposed skin of aged individuals compared with young ones. Materials and Methods: Skin biopsies were taken from normal skin of the back of 22 old subjects (age range: 48-75 years) and 15 young subjects (age range: 18-28 years). Skin sections were stained with hematoxylin and eosin, Masson trichrome, orcein. Epidermal thickness was measured with image analyzer and scoring was done for collagen and elastic fiber degeneration. Fas immunostaining was done. Quantitative and qualitative data were compared statistically between the old and young subjects. Results: A statistically significant decreased epidermal thickness was found in old compared with young skin (P |
| Databáze: | OpenAIRE |
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