Carotenoids and risk of fracture: a meta-analysis of observational studies
| Autor: | Xiaochao Song, Chunli Song, Jiuhong Xu, Xi Zhang, Xinli Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty 030209 endocrinology & metabolism β-cryptoxanthin law.invention carotene 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Prospective cohort study Aged Aged 80 and over Hip fracture 030109 nutrition & dietetics Traditional medicine business.industry Hip Fractures Public health carotenoids lutein/zeaxanthin Middle Aged medicine.disease lycopene Observational Studies as Topic Clinical research Oncology Meta-analysis Dietary Supplements Observational study Female business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Jiuhong Xu 1, * , Chunli Song 2, * , Xiaochao Song 2 , Xi Zhang 3 , Xinli Li 2, 4 1 Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou Jiangsu, PR China, 215006 2 School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, PR China, 215123 3 Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, PR China, 200092 4 Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, PR China, 215123 * These authors contributed equally to this work Correspondence to: Xinli Li, email: lixinli@suda.edu.cn Keywords: carotenoids, carotene, lycopene, β-cryptoxanthin, lutein/zeaxanthin Received: July 02, 2016 Accepted: November 22, 2016 Published: November 29, 2016 ABSTRACT To quantify the association between dietary and circulating carotenoids and fracture risk, a meta-analysis was conducted by searching MEDLINE and EMBASE databases for eligible articles published before May 2016. Five prospective and 2 case-control studies with 140,265 participants and 4,324 cases were identified in our meta-analysis. Among which 5 studies assessed the association between dietary carotenoids levels and hip fracture risk, 2 studies focused on the association between circulating carotenoids levels and any fracture risk. A random-effects model was employed to summarize the risk estimations and their 95% confidence intervals (CIs). Hip fracture risk among participants with high dietary total carotenoids intake was 28% lower than that in participants with low dietary total carotenoids (OR: 0.72; 95% CI: 0.51, 1.01). A similar risk of hip fracture was found for β-carotene based on 5 studies, the summarized OR for high vs. low dietary β-carotene was 0.72 (95% CI: 0.54, 0.95). However, a significant between-study heterogeneity was found (total carotene: I 2 = 59.4%, P = 0.06; β-carotene: I 2 = 74.4%, P = 0.04). Other individual carotenoids did not show significant associations with hip fracture risk. Circulating carotene levels had no significant association with any fracture risk, the pooled OR (95% CI) was 0.83 (0.59, 1.17). Based on the evidence from observational studies, our meta-analysis supported the hypothesis that higher dietary total carotenoids or β-carotene intake might be potentially associated with a low risk of hip fracture, however, future well-designed prospective cohort studies and randomized controlled trials are warranted to specify the associations between carotenoids and fracture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|