Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL
| Autor: | Esteban J. Parra, Craig L. Hanis, Lisa Sanchez-Johnsen, Kristin L. Young, Misa Graff, Yujie Wang, Adán Valladares, Lauren E. Petty, Yii-Der Ida Chen, Xiuqing Guo, Mark O. Goodarzi, Miguel Cruz, Kari E. North, Anny H. Xiang, Leslie J. Raffel, Matthew A. Allison, Tamar Sofer, Yann C. Klimentidis, Shelly Ann Love, Anne E. Justice, Stephanie M. Gogarten, Fernando Pires Hartwig, Thomas A. Buchanan, Jennifer E. Below, Jingyi Tan, Jie Yao, Jerome I. Rotter, Willa A. Hsueh, Eli Ipp, Walter Palmas, Kent D. Taylor, Heather M. Highland, Carmen R. Isasi |
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| Rok vydání: | 2021 |
| Předmět: |
AcademicSubjects/SCI01140
Waist Ethnic group 030209 endocrinology & metabolism Genome-wide association study Biology Polymorphism Single Nucleotide 03 medical and health sciences Quantitative Trait Heritable 0302 clinical medicine Genetics medicine Body Fat Distribution Humans Association Studies Article Molecular Biology Alleles Genetics (clinical) Adiposity 030304 developmental biology Body fat distribution 0303 health sciences Hispanic latino Hispanic or Latino General Medicine medicine.disease Hchs sol Obesity Body mass index Genome-Wide Association Study Demography |
| Zdroj: | Human Molecular Genetics |
| ISSN: | 1460-2083 0964-6906 |
| DOI: | 10.1093/hmg/ddab166 |
| Popis: | Author(s): Justice, Anne E; Young, Kristin; Gogarten, Stephanie M; Sofer, Tamar; Graff, Misa; Love, Shelly Ann M; Wang, Yujie; Klimentidis, Yann C; Cruz, Miguel; Guo, Xiuqing; Hartwig, Fernando; Petty, Lauren; Yao, Jie; Allison, Matthew A; Below, Jennifer E; Buchanan, Thomas A; Chen, Yii-Der Ida; Goodarzi, Mark O; Hanis, Craig; Highland, Heather M; Hsueh, Willa A; Ipp, Eli; Parra, Esteban; Palmas, Walter; Raffel, Leslie J; Rotter, Jerome I; Tan, Jingyi; Taylor, Kent D; Valladares, Adan; Xiang, Anny H; Sanchez-Johnsen, Lisa; Isasi, Carmen R; North, Kari E | Abstract: Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC), and hip circumference (HIP) adjusted for body mass index (adjBMI), using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL; and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban, and Dominican) background residing in the US. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for WHRadjBMI, 22 for WCadjBMI, and 28 for HIPadjBMI that reached suggestive significance (P l 1x10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed 4 novel loci (P l 0.05 and consistent direction of effect, and P l 5x10-8 after meta-analysis), including 2 for WHRadjBMI (rs13301996, rs79478137); 1 for WCadjBMI (rs3168072); and 1 for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI; 10 for WCadjBMI; 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity-susceptibility that may be ancestry-specific. |
| Databáze: | OpenAIRE |
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