Heart Rate Variability and Sensorimotor Polyneuropathy in Type 1 Diabetes
| Autor: | Andrej Orszag, Bruce A. Perkins, Vera Bril, Steven Orlov |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Cohort Studies Young Adult Diabetic Neuropathies stomatognathic system Heart Rate Diabetes mellitus Internal medicine Heart rate Internal Medicine medicine Humans Heart rate variability Motor Neuron Disease Pathophysiology/Complications Original Research Advanced and Specialized Nursing Type 1 diabetes business.industry Respiration Case-control study Arrhythmias Cardiac Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Endocrinology Blood pressure Case-Control Studies Cohort Cardiology Female business Cohort study |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc11-1652 |
| Popis: | OBJECTIVE Reduced heart rate variability (HRV) is classically viewed as an early phenomenon in diabetic sensorimotor polyneuropathy (DSP). We aimed to determine the characteristics of HRV across the spectrum of clinical DSP in type 1 diabetes. RESEARCH DESIGN AND METHODS Eighty-nine diabetic subjects and 60 healthy volunteers underwent assessment of RR interval variation (RRvar) during deep breathing and clinical and electrophysiological examination. We examined the distribution of age-standardized RRvar across the spectrum of clinical DSP, identified variables associated with RRvar in multivariate regression, and compared RRvar with validated measures of neuropathy. RESULTS Age-standardized RRvar had a significant, step-wise, inverse relationship with ordinal categories of increasing DSP severity (β = −5.4, P < 0.0001) among subjects with diabetes. Case subjects with DSP had substantially lower age-standardized RRvar compared with diabetic control subjects without DSP (β = −5.2, P < 0.01), although there was substantial overlap of RRvar between diabetic case subjects and control subjects and the healthy volunteer cohort. In multivariate analysis, advanced age was independently associated with lower RRvar in both healthy volunteers and diabetic subjects, whereas higher glycated hemoglobin A1c and systolic blood pressure were independently associated with lower RRvar in diabetic subjects. RRvar had a significant association with validated measures of large and small fiber neuropathy. CONCLUSIONS HRV may be a biomarker for clinical DSP and is associated cross-sectionally with both early and late measures of neuropathy. The low HRV observed in some control subjects without DSP and in most case subjects with severe DSP may signify that HRV has different prognostic implications in these groups, requiring further longitudinal study. |
| Databáze: | OpenAIRE |
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