Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
| Autor: | Angela E. Schellenberg, Vanessa L. Palmer, Heather T. Whittaker, Jonathan D. Thiessen, Marc R. Del Bigio, Annie Kim, Richard Buist, Blair Cardigan Smith, Sheryl L. Herrera, Melanie Martin |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Pathology medicine.medical_specialty lcsh:R895-920 experimental autoimmune encephalomyelitis H&E stain Optic chiasm Myelin oligodendrocyte glycoprotein 03 medical and health sciences Myelin 0302 clinical medicine medicine magnetic resonance imaging Optic neuritis mouse Original Research 030304 developmental biology 0303 health sciences pertussis toxin biology medicine.diagnostic_test business.industry optic chiasm Experimental autoimmune encephalomyelitis Magnetic resonance imaging medicine.disease Hyperintensity medicine.anatomical_structure biology.protein business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Magnetic Resonance Insights, Vol 7 (2014) Magnetic Resonance Insights, Vol 2014, Iss 7, Pp 23-31 (2014) Magnetic Resonance Insights |
| Popis: | Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)–experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximately 20 days after induction. Hematoxylin and eosin, solochrome cyanin–stained sections, and EM images were obtained from the optic chiasms of some mice approximately 4 days after disease onset when their scores were thought to be the highest. T2-weighted imaging and apparent diffusion coefficient map hyperintensities corresponded to abnormalities in the optic chiasms of EAE mice. Mixed inflammation was concentrated at the lateral surface. Degeneration of oligodendrocytes, myelin, and early axonal damage were also apparent. A marked increase in chiasm thickness was observed. T2-weighted and diffusion-weighted MRI can detect abnormalities in the optic chiasms of MOG-EAE mice. MRI is an important method in the study of this model toward understanding optic neuritis. |
| Databáze: | OpenAIRE |
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