Post-exposure efficacy of Oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model
| Autor: | Mark S. Lever, Robert Lenk, Jackie Steward, Lin Eastaugh, Michelle Nelson, Sophie J. Smither |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Post exposure
viruses Administration Oral Disease Favipiravir medicine.disease_cause Antiviral Agents Mice Virology Case fatality rate Animals Medicine Dosing Mice Knockout Pharmacology Ebola virus business.industry Outbreak Hemorrhagic Fever Ebola Ebolavirus Amides Disease Models Animal Pyrazines Immunology business Ebola virus infection |
| Zdroj: | Antiviral Research. 104:153-155 |
| ISSN: | 0166-3542 |
| DOI: | 10.1016/j.antiviral.2014.01.012 |
| Popis: | Filoviruses cause disease with high case fatality rates and are considered biological threat agents. Licensed post-exposure therapies that can be administered by the oral route are desired for safe and rapid distribution and uptake in the event of exposure or outbreaks. Favipiravir or T-705 has broad antiviral activity and has already undergone phase II and is undergoing phase III clinical trials for influenza. Here we report the first use of T-705 against Ebola virus. T-705 gave 100% protection against aerosol Ebola virus E718 infection; protection was shown in immune-deficient mice after 14 days of twice-daily dosing. T-705 was also shown to inhibit Ebola virus infection in cell culture. T-705 is likely to be licensed for use against influenza in the near future and could also be used with a new indication for filovirus infection. |
| Databáze: | OpenAIRE |
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