Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
| Autor: | Leonardo Trasande, Howard Trachtman, Jingchuan Xue, Kurunthachalam Kannan, Anglina Kataria, Sara Wertenteil, Suzanne Vento, Debra J. Morrison, Elaine M. Urbina, Joshua M. Thurman, Rachel I. Brody, Teresa M. Attina, Karthikraj Rajendiran, Dov Levine |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Adolescent Pilot Projects 010501 environmental sciences 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Phenols Internal medicine medicine.artery Diethylhexyl Phthalate medicine Humans 030212 general & internal medicine Endothelial dysfunction Brachial artery Benzhydryl Compounds Child Pulse wave velocity 0105 earth and related environmental sciences Creatinine business.industry Phthalate medicine.disease 3. Good health Oxidative Stress Endocrinology Cross-Sectional Studies chemistry Pediatrics Perinatology and Child Health Albuminuria Homeostatic model assessment Female Endothelium Vascular medicine.symptom Insulin Resistance business |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. We conducted a cross-sectional pilot study of 10–13 y old healthy children. We assessed descriptive, univariable, and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction. Possible associations with brachial artery distensibility, pulse wave velocity (markers of vascular stiffness), and serum endothelial cell-derived microparticle levels were also assessed. We enrolled 41 participants, 12.1 ± 1.0 y, most of whom were Mexican Americans (42%) or other Hispanics (34%). Increased BPA levels were associated with increased levels of F2-isoprostane (ng/ml) (P = 0.02), with a similar trend for DEHP metabolites. Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with a 0.550 increase in Homeostatic Model Assessment of insulin resistance (HOMA-IR) units (P = 0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P = 0.026). Bisphenol S (BPS), a replacement for BPA, was associated with increased albumin (mg):creatinine (g) ratio (P = 0.04). Metabolites of HMW phthalates were also associated with decreased brachial artery distensibility (P = 0.047). Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children. |
| Databáze: | OpenAIRE |
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