Occupational exposure to polychlorinated biphenyls and risk of cutaneous melanoma: A meta-analysis
| Autor: | Simona Catalani, Cesare Tomasi, Enrico Pira, Paolo Boffetta, Pietro Apostoli |
|---|---|
| Přispěvatelé: | Boffetta, P., Catalani, S., Tomasi, C., Pira, E., Apostoli, P. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cancer Research Skin Neoplasms polychlorinated biphenyls Epidemiology malignant melanoma 010501 environmental sciences meta-analysis Oncology Public Health Environmental and Occupational Health 01 natural sciences Risk Assessment Toxicology 03 medical and health sciences 0302 clinical medicine Internal medicine Occupational Exposure Medicine Humans Melanoma 0105 earth and related environmental sciences business.industry Incidence (epidemiology) Incidence Environmental and Occupational Health 030210 environmental & occupational health Confidence interval Pcb exposure Relative risk Meta-analysis Cutaneous melanoma Occupational exposure Public Health Risk assessment business |
| Popis: | The aim of this study was to carry out a meta-analysis of studies on exposure to polychlorinated biphenyls (PCBs) and the risk of malignant melanoma (MM). We searched Scopus, PubMed, and reference lists; among 807 potentially relevant articles, we selected those based on 12 populations. Data were extracted according to a standardized form; the Newcastle-Ottawa Scale was used to assess study quality. Meta-analyses were carried out according to fixed-effect and random-effects models. The fixed-effect summary relative risk (RR) for MM was 0.91 [95% confidence interval (CI): 0.82-1.00]; the random-effects summary RR was 1.05 (95% CI: 0.78-1.32). The random-effects summary RR from eight occupational cohorts was 1.13 (95% CI: 0.91-1.35) and that from four community-based studies was 0.84 (95% CI: 0.36-1.31). The quality of the studies and the methods for PCB exposure assessment did not influence the RR. These results do not support the hypothesis of an association between PCB exposure and the risk of MM. © 2017 Wolters Kluwer Health, Inc. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|