Loss of T cells influences sex differences in stress-related gene expression
| Autor: | Kelly C. Rilett, Karen-Anne McVey-Neufeld, Owen D. Luo, Jane A. Foster, Robyn N. MacKenzie |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Restraint Physical 0301 basic medicine medicine.medical_specialty Neuroimmunomodulation T-Lymphocytes Immunology Receptors Antigen T-Cell Adaptive Immunity Biology Psychological Distress Stress (mechanics) Mice 03 medical and health sciences 0302 clinical medicine Internal medicine Gene expression medicine Animals Immunology and Allergy Mice Knockout Sex Characteristics T-cell receptor Wild type Brain T lymphocyte Acquired immune system Mice Inbred C57BL Sexual dimorphism 030104 developmental biology Endocrinology Neurology Female Neurology (clinical) Transcriptome Stress reactivity 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmunology. 343:577213 |
| ISSN: | 0165-5728 |
| Popis: | Deficiencies in the adaptive immune system have been linked to anxiety-like behaviours and stress reactivity. Mice lacking T lymphocytes through knockout of the T cell receptor (TCR) β and δ chains were compared to wild type C57Bl/6 mice. Central stress circuitry gene expression was assessed following repeated restraint stress. TCRβ-/-δ-/- mice showed an increased baseline plasma corticosterone and exaggerated changes in stress-related gene expression after repeated restraint stress. Sexual dimorphic stress responses were observed in wild-type C57Bl/6 mice but not in TCRβ-/-δ-/- mice. These data suggest that T cell-brain interactions influence sex-differences in CNS stress circuitry and stress reactivity. |
| Databáze: | OpenAIRE |
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