Assessment of various intralesional injections in keloid: comparative analysis
| Autor: | Fathia M Khattab, Waleed Albalat, Sara Nabil |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty Triamcinolone acetonide Skin Injury business.industry Dermatology Injections Intralesional medicine.disease Triamcinolone Acetonide 030207 dermatology & venereal diseases 03 medical and health sciences Treatment Outcome 0302 clinical medicine Keloid Verapamil Intralesional injections Platelet-rich plasma medicine Humans Fluorouracil skin and connective tissue diseases business medicine.drug |
| Zdroj: | Journal of Dermatological Treatment. 33:2051-2056 |
| ISSN: | 1471-1753 0954-6634 |
| Popis: | In reaction to skin injury in genetically predisposed persons, the keloid is formed and marked by benignant overgrowth of dermic collagen. Intralesional triamcinolone was used in the treatment of keloids with varying results.Intralesional triamcinolone is a gold standard in treating the keloids in comparison with its effectiveness versus intralesional 5-fluorouracil intralesional verapamil and intralesional platelet-rich plasma.Several 160 cases were categorized into four groups of each group-containing 40 cases. Group-A (control) treated with intralesional triamcinolone and Group-B intralesional verapamil, Group-C intralesional 5-fluorouracil, and Group-D intralesional platelet-rich plasma. Patients were assessed for clinical response based on a decrease in the patient and observer scar assessment scale (POSAS) at baseline and the end of treatment.The mean base-line POSAS score was 91 ± 10.98 SD check-in Group-A, 90 ± 10.85 in Group-B, 89 ± 10.06 in Group-C, and 92 ± 10.84 in Group-D. POSAS score after 24 weeks 36 ± 12.74 in Group-A, 29 ± 10.91 in Group-B, 39 ± 13.74 in Group-C, 36 ± 12.74 in Group-D. Statistically, a significant difference was observed between groups.Intralesional verapamil reported to be the most effective therapy and platelet-rich plasma was effective as intralesional triamcinolone acetonide with no serious side effects and 5-fluorouracil was less effective in treating the keloids. |
| Databáze: | OpenAIRE |
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