Bronchial hyperresponsiveness induced by chronic treatment with albuterol: Role of sensory nerves
| Autor: | Clive P. Page, Domenico Spina, Sandra Keir |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Bronchoconstriction Guinea Pigs Immunology Bradykinin Bronchi Pharmacology Bronchoconstrictor Agents chemistry.chemical_compound Airway resistance Desensitization (telecommunications) Animals Immunology and Allergy Medicine Albuterol Neurons Afferent Peripheral Nerves Leukotriene Dose-Response Relationship Drug Leukotriene C4 business.industry Stereoisomerism Adrenergic beta-Agonists medicine.disease Bronchodilator Agents respiratory tract diseases medicine.anatomical_structure chemistry Capsaicin Bronchial hyperresponsiveness business Sensory nerve |
| Zdroj: | Journal of Allergy and Clinical Immunology. 110:388-394 |
| ISSN: | 0091-6749 |
| DOI: | 10.1067/mai.2002.126661 |
| Popis: | It has recently been suggested that regular treatment with racemic beta(2)-adrenoceptor agonists might result in bronchial hyperresponsiveness (BHR) to a range of spasmogens, and this might be due to adverse effects of the distomer.We sought to determine whether BHR induced by means of continuous exposure to racemic and S-albuterol was mediated by sensory nerves.Naive or ovalbumin-sensitized guinea pigs were treated for 10 days with RS-, R-, or S-albuterol (1 mg.kg(-1).d(-1)) through subcutaneously implanted minipumps. Lung function was then determined in response to a number of spasmogens and assessed on the basis of an increase in total airway resistance. A separate group of animals were chronically treated with capsaicin (80 mg/kg) before the albuterol treatment.Treatment with RS- or S-albuterol increased airway responsiveness to bradykinin, leukotriene C(4), and capsaicin in naive guinea pigs (P.05) and to histamine and ovalbumin in immunized guinea pigs (P.05). Chronic treatment with capsaicin prevented the development of RS- and S-albuterol-induced BHR in these models. The bronchodilator efficacy of acute intravenously administered RS-albuterol was unaffected in RS-, R-, or S-albuterol-treated guinea pigs compared with in vehicle-treated animals.We have provided evidence demonstrating that continuous exposure to RS- and S-albuterol increases bronchial responsiveness to a range of stimuli, an effect not attributed to beta-adrenoceptor occupancy or desensitization. Furthermore, capsaicin-sensitive sensory nerves mediate the development of BHR, at least in part. |
| Databáze: | OpenAIRE |
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