Predicting the risk of portal vein thrombosis in patients with liver cirrhosis and hepatocellular carcinoma
| Autor: | Magdy M. Mohamed, Waleed Mohamed Serag, Bedoor Shehap eldeen Mohammed, Basem Eysa Elsayed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Portal flow velocity medicine.medical_specialty Cirrhosis Immunology Inflammation Pathophysiology Gastroenterology Article Clinical research 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Platelet lcsh:Social sciences (General) lcsh:Science (General) Multidisciplinary Plasma annexin A5 /PS+MP ratio business.industry Phosphatidylserine Laboratory medicine medicine.disease Portal vein thrombosis Plasma AnxA5 level 030104 developmental biology chemistry PhosphatidylSerine bearing microparticles (PS+MPs) levels Hematological system Hepatocellular carcinoma lcsh:H1-99 medicine.symptom Annexin A5 business 030217 neurology & neurosurgery lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 6, Iss 8, Pp e04677-(2020) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | The mechanisms of the hypercoagulable state in cirrhotics with and without hepatocellular carcinoma are incompetently comprehended. Objective: We aimed to explore the plasma Annexin A5/PS + MP ratio in these patients. Higher levels of Annexin A5 and PhosphatidylSerine bearing microparticles have been observed in cases of inflammation and increased coagulation but there are no studies which explore if there is an association between them and PVT in cirrhotics with and without HCC. So, our goal is to estimate their role in predicting PVT within HCV cirrhotics with and without HCC. 91 HCV cirrhotics with and without HCC and 20 healthy people (controls) were enlisted. Cirrhotics with and without HCC who developed PVT displayed higher levels of PS + MPs and lower Annexin A5/PS + MPs ratio (38.73 ± 1.92) and (0.00238 ± 0.00047) than cirrhotics who didn't develop PVT (22.19 ± 10.58) and (0.00451 ± 0.0023) (P < 0.001). Among the tested factors, lower Annexin A5/PS + MPs ratio show higher performance in predicting PVT in total cirrhotics, AUC, 0.919 followed by PS + MPs level, 0.876, Portal flow velocity, 0.842, Plasma Annexin A5 level, 0.509. In our hypothesis, As phosphatidylserine exposure increase due to increased level of circulating microparticles in cirrhotics with and without HCC, anenxin-A5 may be secreted by platelets and endothelial cells into the circulation as a physiological response to inactivate the elevated levels of PS bearing MPs produced in these patients but the increase in anenxin-A5 level isn't equivalent to the increase in PS bearing MPs levels. The equilibrium between plasma annexin A5 and PS bearing MPs levels is defected. Inflammation; Pathophysiology; Hematological System; Immunology; Laboratory Medicine; Clinical Research; Portal vein thrombosis; PhosphatidylSerine bearing microparticles (PS + MPs) levels; plasma AnxA5 level; plasma Annexin A5/PS + MP ratio; Portal flow velocity. |
| Databáze: | OpenAIRE |
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