Final report on the second British Institute of Radiology fractionation study: short versus long overall treatment times for radiotherapy of carcinoma of the laryngo-pharynx
| Autor: | G. Wiernik, C. J. Alcock, T. D. Bates, J. M. Brindle, J. F. Fowler, W. R. Gajek, S. Goodman, J. L. Haybittle, J. M. Henk, J. W. Hopewell, R. D. Hunter, R. Lindup, D. L. Phillips, M. Rezvani |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Fractionation medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Prospective Studies Laryngeal Neoplasms Aged Aged 80 and over business.industry Treatment regimen Pharynx Dose fractionation Pharyngeal Neoplasms Radiotherapy Dosage General Medicine Middle Aged medicine.disease Surgery Squamous carcinoma Radiation therapy Survival Rate medicine.anatomical_structure Total dose Carcinoma Squamous Cell Female Radiology business Nuclear medicine |
| Zdroj: | The British journal of radiology. 64(759) |
| ISSN: | 0007-1285 |
| Popis: | The second British Institute of Radiology trial of dose fractionation in radiotherapy compared two groups of prospectively randomized patients with squamous carcinoma of the laryngo-pharynx; one group was treated in a short (less than or equal to 4 weeks) and the other in a long (greater than 4 weeks) overall time. Treatment in any one centre could be given, with no planned gap in the course of treatment, either as a conventional, daily (5 fractions per week regime) or as 3 fractions per week. A total of 611 patients were allocated to treatment, of whom nine have had to be excluded from the analysis for a lack of information. Patients were admitted to the trial from January 1976 to December 1985 and were followed up for a maximum of 10 years and a minimum of 3 years. A reduction in total dose was made for use in the short compared with the long treatment regime. This reduction in total dose varied between 18% and 22% depending on whether 5 fractions or 3 fractions per week regimes were used. Overall, no statistically significant differences have been found between the two arms of the trial. The patients treated with 5 fractions per week in a short overall treatment time showed fewer late normal tissue effects. An analysis based on stratification by age, stage and anatomical site gave a relative risk (short/long overall treatment time) for deaths of 1.23 with a 95% confidence interval from 0.96 to 1.59. Analyses stratified for stage and site gave relative risks with 95% confidence intervals of 1 x 10 (0.84-1.44) for local recurrences/tumour persistence, and 1.01 (0.70-1.45) for laryngectomies. |
| Databáze: | OpenAIRE |
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