Antivirals Targeting the Neuraminidase
| Autor: | Teena Mohan, Larisa V. Gubareva |
|---|---|
| Rok vydání: | 2024 |
| Předmět: |
0301 basic medicine
Oseltamivir medicine.drug_class Neuraminidase Monoclonal antibody Antiviral Agents General Biochemistry Genetics and Molecular Biology Epitope 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Zanamivir Drug Resistance Viral Influenza Human medicine Humans Enzyme Inhibitors biology Chemistry Antibodies Monoclonal Virology Laninamivir 030104 developmental biology Viral replication 030220 oncology & carcinogenesis biology.protein Peramivir medicine.drug |
| Zdroj: | Cold Spring Harbor perspectives in medicine. 12(1) |
| ISSN: | 2157-1422 |
| Popis: | The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that competitively bind to the NA active site and potently inhibit enzyme activity have been synthesized and tested. Four NA inhibitors are now licensed in various parts of the world (zanamivir, oseltamivir, peramivir, and laninamivir) to treat influenza A and B infections. NA changes, naturally occurring or acquired under selective pressure, have been shown to reduce drug binding, thereby affecting the effectiveness of NA inhibitors. Drug resistance and other drawbacks have prompted the search for the next-generation NA-targeting therapeutics. One of the promising approaches is the identification of monoclonal antibodies (mAbs) targeting the conserved NA epitopes. Anti-NA mAbs demonstrate Fab-based antiviral activity supplemented with Fc-mediated immune effector functions. Antiviral Fc-conjugates offer another cutting-edge strategy that is based on a multimodal mechanism of action. These novel antiviral agents are composed of a small-molecule NA inhibitor and an Fc-region that simultaneously engages the immune system. The significant advancements made in recent years further support the value of NA as an attractive target for the antiviral development. |
| Databáze: | OpenAIRE |
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