Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Autor: Miguel Fiol, Patricia Guillem-Saiz, Leticia Miró-Moriano, Josep A. Tur, N. Ibarrola, A.I. Castellote-Bargalló, J. Boj, Estefanía Toledo, Ana Jover, V. Extremera-Urabayen, E. Manzano, I. González-Monje, Juan Carlos Martínez-González, María P. Portillo, O. Portolés, C. Simón, Olga Castañer, B. Sanjulián, S. Sánchez-Navarro, R. González, Rosa M. Lamuela-Raventós, R. Pedret, N. Tort, J. Pérez-Cabrera, J. García, J. Portu-Zapirain, Carolina Ortega-Azorín, Dolors Montañes, Helmut Schröder, Guillermo Frontera, Mònica Bulló, Lluis Serra-Majem, J.M. Santos-Lozano, F. Trias, Nuria Rosique-Esteban, P. Martínez, C. Iglesias, Magí Farré, J.M. Lozano-Rodriguez, Valentina Ruiz-Gutiérrez, Luis Forga, L.T. Casañas-Quintana, I. Sarasa, C. de Juan, R. Benítez Pont, Javier Díez-Espino, L. Parra, M. Ginard, Josep Basora, Luis V. García, Rosa Casas, Fernando Arós, L. Quinzavos, A. Larrauri, A. Guarner, Ramon Estruch, A.M. Alonso-Gómez, Aleix Sala-Vila, E. Montero Romero, Cinta Valls-Pedret, F. Bestard, Jesús Berjón, Y. García, José Manuel Santos-Lozano, Emili Corbella, J. Clos, Christopher Papandreou, E. Maestre, R.E. Sosa-Also, J. Altirriba, M. Bianchi Alba, José I. González, Eva M. Asensio, Paula Carrasco, J. Vila, J.A. García Pastor, J. Medina-Ponce, Jordi Salas-Salvadó, L. Mellado, Amelia Marti, Estíbaliz Goñi, Joan Fernández-Ballart, Ana García-Arellano, Pilar Roura, Albert Salas-Huetos, A. Loma-Osorio, E. Jurado-Ruiz, Casandra Riera, Pilar Buil-Cosiales, Ana Galera, J. Gil Zarzosa, Miquel Fiol, Fabiola Márquez, Alfredo García-Layana, Maria Luisa García, B.V. Díaz-González, M.A. Pages, Enrique Gómez-Gracia, D. Godoy, F. Paris, T. del Hierro, F. Cortés-Ugalde, Ernest Vinyoles, J. Marrugat, V. Velasco García, Olga Portolés, F. Sarmiento de la Fe, Roberto Elosua, F.J. García-Corte, J. Timiraus-Fernández, Ana Pérez-Heras, P. Baby, M. Aldamiz-Echevarría, Montse Cofán, Y. Corchado, J. Villanueva-Telleria, T. Sagredo-Arce, C. Valero-Barceló, M.C. Belló, J. Frigola, J.J. Cabré, B. Churio-Beraza, Montserrat Fitó, P. Román, A. Proenza, M.C. López Sabater, P. Iglesias, J.M. Baena, M.T. Martín, Javier Rekondo, S. Vaquero-Diaz, G. Mestres, Nancy Babio, J. Diez-Espino, M. Liroz, M. García-Valdueza, J. Gállego, J.M. Castillo Anzalas, M.V. Gueto Rubio, L. Coll, S. Tello, Manuel Moñino, Anna Tresserra-Rimbau, Susana Munuera, J. Sánchez Perona, Guillermo T. Sáez, Gemma Flores, J. Amat, J. Benavent, M. Sorlí, Manuel Ortega-Calvo, A. Altés, Dolores Corella, Inmaculada Bautista-Castaño, Jacqueline Álvarez-Pérez, Marisa Guillén, Rafel M. Prieto, Ángel M. Alonso-Gómez, A. Ramos, Daniel Muñoz-Aguayo, M.A. Rovira, E. de la Cruz, Manuel Serrano-Martínez, A. Urtasun-Samper, R. Osma, R. de la Torre, J. Basells, N. Berrade, Jaime Algorta, R. Segarra, I. Duaso, Emilio Ros, C. Domínguez-Espinaco, J.A. Munar, A. Brau, M.I. Santamaría, A. Medina-Renom, Mercè Serra-Mir, Jesús Vizcaíno, J. de Diego Salas, M. Amorós, Z. Vázquez, Ana María Castro, E. Sanz, M. García-García, F. Fiol, F.J. Giménez, Itziar Salaverria, M. Vivó, Elena H. Martinez-Lapiscina, C. Viñas, J. García Roselló, A. Baca Osorio, A. Carratalá-Calvo, Francesc Francés, Julia Wärnberg, C. Arroyo-Azpa, Rebeca Fernández-Carrión, E.M. Díaz-Benítez, O. Coltell, Miguel Ruiz-Canela, M.D. Vigata-López, F. Martin, M.S. Sánchez, L. Mengual, Mónica Doménech, V. Pascual, Nerea Becerra-Tomás, Ricardo Gómez-Huelgas, Xavier Corbella, M.C. Yuste, E. Vargas López, Carmen Saiz, J.J. Sánchez Luque, I. Pla, S. Francisco, F. Aros, Marta Guasch-Ferré, Almudena Sánchez-Villegas, A. Isach, Ariadna Rovira, Marta Fanlo-Maresma, Carmen Cabezas, Dora Romaguera, L. Garcia-Pérez, M. Oller, M.T. Bonet, M. Mata, Sonia Eguaras, Ana Sánchez-Tainta, M. Llauradó, J. Costa-Vizcaino, Laura Quiles, Paola Quifer-Rada, C. Molina, N. Molina, M.T. Arceiz Campo, Cristina Ruano-Rodríguez, J.M. Verdú, Rocío Barragán, Andrés Díaz-López
Rok vydání: 2018
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Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
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Popis: Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005.
The authors disclose no conflict of interest related with the article. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds (CB06/03). Supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through grants provided to research networks specifically developed for the trial (RTIC G03/140 and RD 06/0045) through CIBEROBN, and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–FondoEuropeo de Desarrollo Regional (PI04–2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and PI11/02505; PI13/00462), Ministerio de Ciencia e Innovación (AGL-2009–13906-C02 and AGL2010–22319-C03), Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVA-COMP2010–181, GVACOMP2011–151, CS2010-AP-111, and CS2011-AP-042), and the Navarra Regional Government (27/2011). The Fundación Patrimonio Comunal Olivarero and Hojiblanca SA (Málaga, Spain), California Walnut Commission (Sacramento, CA), Borges SA (Reus, Spain), and Morella Nuts SA (Reus, Spain) donated the olive oil, walnuts, almonds, and hazelnuts, respectively, used in the study. None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. Acknowledgements: The authors thank all the participants for their collaboration, all the PREDIMED personnel for their assistance and all the personnel of affiliated primary care centers for making the study possible. CIBEROBN is an initiative of ISCIII, Spain.
Databáze: OpenAIRE
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