Impact of Anti-GPIIb/IIIa Antibody-Producing B Cells as a Predictor of the Response to Lusutrombopag in Thrombocytopenic Patients with Liver Disease
| Autor: | Makoto Kako, Takahiro Suzuki, Haruki Uojima, Norio Itokawa, Shuichiro Iwasaki, Tatehiro Kagawa, Sosei Okina, Ryouichi Horie, Xue Shao, Koji Miyazaki, Hayato Takiguchi, Yoshitaka Arase, Katsuhiko Iwakiri, Naohisa Wada, Masanori Atsukawa, Takashi Satoh, Wasaburo Koizumi, Hisashi Hidaka |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Platelet Glycoprotein GPIIb-IIIa Complex Chronic liver disease Gastroenterology Liver disease Internal medicine medicine Humans Platelet Prospective Studies Receptor Prospective cohort study Thrombopoietin Aged Autoantibodies Aged 80 and over B-Lymphocytes biology business.industry Platelet Count Liver Diseases Autoantibody General Medicine Organ Size Middle Aged medicine.disease Thrombocytopenia Thiazoles Cinnamates Multivariate Analysis biology.protein Female Antibody business Spleen Liver: Research Article |
| Zdroj: | Dig Dis |
| ISSN: | 1421-9875 |
| Popis: | Background: To make an accurate estimate of the response to thrombopoietin (TPO) receptor agonists for thrombocytopenia associated with chronic liver disease, we evaluated the influence of antiplatelet autoantibodies on the response to lusutrombopag in thrombocytopenic patients with liver disease. Methods: A prospective study was conducted at 2 hospitals. Thrombocytopenic patients with liver disease received oral lusutrombopag 3.0 mg once daily for up to 7 days. We analyzed changes in platelet counts from baseline to the maximum platelet count on days 9–14. The definition of clinical response was a platelet count of ≥5 × 104/μL with an increased platelet count of ≥2 × 104/μL from baseline. We assessed the correlation between the response to treatment drug and antiplatelet autoantibodies measured by anti-GPIIb/IIIa antibody-producing B cells. Results: Thirty patients received the trial drug. There were 25 responders and 5 nonresponders. The median change in platelet counts was 3.9 × 104/μL (95% CI 2.8–4.6, p < 0.0001). The correlation between change in platelet counts and the frequency of the anti-glycoprotein IIb/IIIa antibody-producing B cells was moderate (r = 0.414, 95% CI 0.064–0.674, p = 0.023). In multivariate analysis of factors affecting the change in platelet counts, the anti-GPIIb/IIIa antibody-producing B cells were identified as an independent factor (regression coefficient [B] = 0.089; CI 0.021–0.157, p = 0.013). Conclusion: Anti-GPIIb/IIIa antibody-producing B cells may be a predictor for TPO receptor agonists in patients with chronic liver disease. |
| Databáze: | OpenAIRE |
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