Controlled comparison of the efficacy and safety of cetirizine 10 mg o.d. and fexofenadine 120 mg o.d. in reducing symptoms of seasonal allergic rhinitis
| Autor: | A. Kavina, F Donnelly, C. De Vos, Friedrich Horak, P. Stübner, R. Zieglmayer, B. Burtin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Allergy Immunology medicine.disease_cause Placebo Poaceae Sneezing Bronchial Provocation Tests Allergen Double-Blind Method Anti-Allergic Agents medicine Immunology and Allergy Humans Fexofenadine Cross-Over Studies business.industry Rhinitis Allergic Seasonal Aeroallergen General Medicine medicine.disease Crossover study Cetirizine Kinetics Toxicity Pollen Female Terfenadine business medicine.drug |
| Zdroj: | International archives of allergy and immunology. 125(1) |
| ISSN: | 1018-2438 |
| Popis: | Background: The efficacy, onset and duration of action and safety of cetirizine 10 mg o.d., fexofenadine 120 mg o.d., and placebo were compared in this investigator-blinded, crossover study involving the use of the Vienna Challenge Chamber. Methods: 40 volunteers with seasonal allergic rhinitis were exposed to a controlled grass pollen concentration for 6 h on 2 consecutive days. Subjective symptoms and objective measurements were recorded during the allergen exposure periods. Results: Both active medications were significantly more effective than placebo and had a comparable onset of action in alleviating the symptoms of seasonal allergic rhinitis. The efficacy of both active drugs was comparable for the first 4 h after administration of the drugs on day 1 and day 2. However from 22 to 24 h after the first dose cetirizine was significantly superior to fexofenadine for the major symptom complex score and for sneezing. Concerning the total symptom complex score at day 2 fexofenadine could not reach superiority to placebo. No serious adverse events were reported. Conclusions: Cetirizine and fexofenadine were significantly better than placebo, also in reducing the symptom of nasal congestion. However cetirizine appears to have a longer duration of action than fexofenadine. |
| Databáze: | OpenAIRE |
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