Longitudinal follow‐up of biopsy‐proven small fiber neuropathy
| Autor: | Steven MacDonald, Yuebing Li, Taral R. Sharma, David Polston, Jianbo Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Employment Male 0301 basic medicine Average duration medicine.medical_specialty Adolescent Physiology Biopsy Small Fiber Neuropathy 030105 genetics & heredity Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Pain control Physiology (medical) Retrospective analysis Humans Medicine Longitudinal Studies Mobility Limitation Aged Retrospective Studies Aged 80 and over Analgesics medicine.diagnostic_test business.industry Middle Aged Prognosis Surgery Autonomic Nervous System Diseases Neuropathic pain Neuralgia Female Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Muscle & Nerve. 60:376-381 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/mus.26648 |
| Popis: | Introduction Little is published on the prognosis of small fiber neuropathy (SFN). Methods A retrospective analysis of 101 patients with biopsy proven SFN. Results Study participants included 87 patients with length-dependent SFN and 14 patients with non-length-dependent SFN. The average duration of symptoms was 3.2 years prior to SFN diagnosis, and the average follow-up duration after diagnosis was 6.2 years. Neuropathic pain was present in 98% of patients and in 84.2% of patients at the final visit. The average total number of pain medications ever used was 4.4 per patient. Signs of autonomic dysfunction were initially present in 24.8% of patients, but improved in most. Large fiber involvement was seen in 11.9% of patients. Small fiber neuropathy affected employment and ambulation status in 5.3% and 6.3% of patients, respectively. Discussion Small fiber neuropathy tends to be stable and rarely affects ambulation and employment status. Effective pain control remains a challenge. |
| Databáze: | OpenAIRE |
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