| Autor: |
K. Buvanesvaragurunathan, J. Ganesh, S. Nagul Kumar, V. Porchezhiyan, A. Radha, P. Azhahianambi, P. Pandikumar, S. Ignacimuthu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Experimental Parasitology. :108258 |
| ISSN: |
0014-4894 |
| DOI: |
10.1016/j.exppara.2022.108258 |
| Popis: |
Glycyrrhetinic acid (GA) is one of the important Pentacyclic Triterpenoids (PT) found in the roots of licorice. This study aimed to evaluate the in vitro growth inhibitory effect of 18β-GA (18β-Glycyrrhetinic acid) and C-30 esters against Theileria annulata, the causative agent of Tropical Bovine Theileriosis. C-30 esters of 18β-GA were synthesized and their structures were elucidated using spectroscopy. The pharmacodynamic properties of 18β-GA and its C-30 esters were predicted using DataWarrior and Swiss ADME tools. Cattle isolates of T. annulata schizont-infected bovine lymphoblastoid cells were cultured using standard conditions and the growth inhibitory effect of GA and its esters were evaluated using MTT assay. The isopropyl ester of 18β-GA (GI |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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