Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature

Autor: Angelo Cangiano, Silvestro Canonico, Massimo De Falco, Gianluca Pellino, Nadia De Falco, Maria Giulia Sommella, Giuseppe Santangelo, Marina Accardo, Fabrizio Chirico, Domenico Parmeggiani, A Cosenza, Andrea Ronchi
Přispěvatelé: De Falco, N., Santangelo, G., Chirico, F., Cangiano, A., Sommella, M. G., Cosenza, A., Ronchi, A., Accardo, M., Pellino, G., Parmeggiani, D., Canonico, S., De Falco, M.
Rok vydání: 2021
Předmět:
Male
endocrine system
Pathology
medicine.medical_specialty
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Surgical approach
Thyroid Gland
Case Report
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Thyroid cancer
Iodine Radioisotopes
Neoplasms
Multiple Primary
Thyroid carcinoma
03 medical and health sciences
0302 clinical medicine
medicine
Carcinoma
Humans
Thyroid Neoplasms
Parathyroid cancer
Radionuclide Imaging
Hyperparathyroidism
lcsh:RC648-665
business.industry
General Medicine
Middle Aged
medicine.disease
Intrathyroidal Parathyroid
Parathyroid Neoplasms
medicine.anatomical_structure
Parathyroid carcinoma
Thyroid Cancer
Papillary
030220 oncology & carcinogenesis
Parathyroid gland
business
Intrathyroidal parathyroid
Primary hyperparathyroidism
Zdroj: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Endocrine Disorders
ISSN: 1472-6823
Popis: Background Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroidal localization of a parathyroid gland is not frequent with a reported prevalence of 0.2%. Carcinoma of parathyroids with intrathyroidal localization represents an even rarer finding, reported in only 16 cases described in literature. The rare constellation of synchronous parathyroid and thyroid carcinomas has prompted us to report our experience and perform literature review. Case presentation We herein report a case of a 63-years-old man with multinodular goiter and biochemical diagnosis of hyperparathyroidism. Total thyroidectomy with radio-guide technique using gamma probe after intraoperative sesta-MIBI administration and intraoperative PTH level was performed. The high radiation levels in the posterior thyroid lobe discovered an intrathyroidal parathyroid. Microscopic examination revealed a parathyroid main cell carcinoma at the posterior thyroidal left basal lobe, a classic papillary carcinoma at the same lobe and follicular variant of papillary carcinoma at the thyroidal right lobe. To the best of our knowledge, this is the first case documenting a synchronous multicentric non medullary thyroid carcinomas and intrathyroidal parathyroid carcinoma. Conclusions Our experience was reported and literature review underlining challenging difficulties in diagnostic workup and surgical management was carried out.
Databáze: OpenAIRE
Externí odkaz: