Clinical significance of aortic stiffness, carotid intima-media thickness and serum osteoprotegerin level in rheumatoid arthritis patients
| Autor: | Izzet Selcuk Parlak, Cem Ozisler, Fulya Dortbas, Aşkın Ateş, Kubilay Şahin, Hüseyin Tutkak, Ozgul Ucar Elalmis, Yaşar Karaaslan |
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| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
musculoskeletal diseases 030203 arthritis & rheumatology medicine.medical_specialty business.industry Cardiovascular risk factors medicine.disease 03 medical and health sciences 0302 clinical medicine Rheumatology Intima-media thickness Osteoprotegerin Rheumatoid arthritis Internal medicine cardiovascular system Cardiology Medicine Clinical significance Aortic stiffness In patient 030212 general & internal medicine Risk factor lcsh:RC581-607 business |
| Zdroj: | Egyptian Rheumatologist, Vol 41, Iss 2, Pp 111-115 (2019) |
| ISSN: | 1110-1164 |
| DOI: | 10.1016/j.ejr.2018.07.002 |
| Popis: | Aim of the work: Cardiovascular diseases represent a major source of morbidity and mortality for patients with rheumatoid arthritis (RA). The increase in aortic stiffness, carotid intima-media thickness (CIMT) and serum osteoprotegerin (OPG) have been shown to be independent risk factors for cardiovascular events. This work aimed to investigate the clinical significance of these parameters in RA patients. Patients and methods: 60 RA patients and 30 control with no primary cardiovascular risk factors were included. Disease activity score (DAS28) was assessed in patients. Aortic stiffness was evaluated by transthoracic echocardiography and CIMT evaluated by Doppler ultrasonography. OPG was determined by ELISA. Results: The 60 RA patients had a mean age of 40.8 ± 8.3 years, disease duration of 6.9 ± 4.9 years and were 46 females and 14 males. In RA patients, serum OPG and CIMT (thickest and mean) were significantly higher than the control (60.5 ± 32.4 pg/ml vs 29.4 ± 16.7 pg/ml, p |
| Databáze: | OpenAIRE |
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