Synthesis, DNA-binding, DNA-photonuclease profiling and antimicrobial activity of novel tetra-aza macrocyclic Ni(II), Co(II) and Cu(II) complexes constrained by thiadiazole
| Autor: | S.M. Pradeepa, H. Joy Hoskeri, M. C. Prabhakara, D. Girija, N. Sharath, B. Vinay Kumar, H. S. Bhojya Naik |
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| Rok vydání: | 2012 |
| Předmět: |
Macrocyclic Compounds
Light Spectrophotometry Infrared Stereochemistry Electrons Microbial Sensitivity Tests Ligands Nucleic Acid Denaturation Absorption Analytical Chemistry Metal chemistry.chemical_compound Anti-Infective Agents Coordination Complexes Nickel Thiadiazoles Octahedral molecular geometry Polymer chemistry Instrumentation Spectroscopy Deoxyribonucleases Bacteria biology Viscosity Electric Conductivity Fungi Temperature Cobalt DNA Antimicrobial biology.organism_classification Atomic and Molecular Physics and Optics chemistry visual_art visual_art.visual_art_medium Tetra pUC19 Macrocyclic ligand Copper Acetamide Plasmids |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 94:192-199 |
| ISSN: | 1386-1425 |
| Popis: | A new tetra-aza macrocyclic ligand, L (C24H16N12O2S4) and its complexes of type, [MLCl2] and [CuL]Cl2 (where M = Ni(II), Co(II); L = N,N′-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide}) were synthesized and characterized by the spectral and analytical techniques. An octahedral geometry has been proposed for Ni(II) and Co(II) complexes while Cu(II) complex exhibit a square planar geometry. All the synthesized metal complexes were screened for their in vitro antimicrobial activity against selected species of pathogenic bacteria and fungi. The binding property of the complexes with CT-DNA was studied by absorption spectral analysis, followed by viscosity measurement and thermal denaturation studies. The photo induced cleavage studies revealed that the complexes possess photonuclease property against pUC19 DNA under UV–visible irradiation. |
| Databáze: | OpenAIRE |
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