Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia
| Autor: | Maria I. Zervou, Peggy Kanellou, Irene Mavroudi, Semeli Mastrodemou, Maria Ximeri, Helen A. Papadaki, Katerina Pyrovolaki, Helen Koutala, Aristides G. Eliopoulos, Athina Damianaki, Charalampos Pontikoglou, George N. Goulielmos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Neutropenia Adolescent Increased IgM level CD40 Ligand Immunology B-Lymphocyte Subsets Immunoglobulins chemical and pharmacologic phenomena Immunoglobulin D Immunoglobulin G Young Adult 03 medical and health sciences medicine Humans Immunology and Allergy CD40 Antigens B cell Aged B-Lymphocytes biology business.industry hemic and immune systems Middle Aged medicine.disease Immunoglobulin Class Switching Tumor Necrosis Factor Receptor Superfamily Member 7 030104 developmental biology medicine.anatomical_structure Immunoglobulin M Immunoglobulin class switching Case-Control Studies Chronic Disease biology.protein Female Antibody business Signal Transduction |
| Zdroj: | Clinical Immunology. 183:75-81 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2017.07.009 |
| Popis: | Chronic idiopathic neutropenia (CIN) is a granulocytic disorder associated with presence of activated, myelosuppressive T-lymphocytes. In the present study we have evaluated constituents of humoral immunity in CIN patients (n=48) compared to healthy controls (n=52). CIN patients displayed lower serum IgG levels due to a reduction in IgG1, IgG3, IgG4 but not IgG2, lower IgA and increased IgM levels compared to controls. The proportion of CD19+ cells did not differ between patients and controls; however the proportion of the naive IgD+/CD27- B-cells was increased and the proportion of class-switched memory IgD-/CD27+ B-cells was decreased in the patients. The percentage of CD40+ B-cells did not differ between patients and controls and no aberrations in the CD40-meadiated signal transduction pathway or in CD40-gene polymorphisms were identified. These data provide further evidence that immune disturbances are associated with the pathophysiology of CIN and point out for the first time the implication of the B-cell system. |
| Databáze: | OpenAIRE |
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