Shift of Enterovirus species among children in Cameroon--identification of a new enterovirus, EV-A119
| Autor: | Ferdinand Tah, Magnus Lindh, Jean-Claude Kabayiza, James A. Ayukekbong, Theresia Nkuo-Akenji, Tomas Bergström, Helene Norder |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Echovirus Adolescent Molecular Sequence Data Coxsackievirus medicine.disease_cause Asymptomatic Feces Viral Proteins Virology medicine Enterovirus Infections Cluster Analysis Humans Cameroon Child Phylogeny Enterovirus biology Foot-and-mouth disease Outbreak Aseptic meningitis Genetic Variation Sequence Analysis DNA biology.organism_classification medicine.disease Infectious Diseases Child Preschool RNA Viral Female medicine.symptom 5' Untranslated Regions Meningitis |
| Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 58(1) |
| ISSN: | 1873-5967 |
| Popis: | Background Infections caused by human enteroviruses (EVs) are often asymptomatic or mild, although they may cause more severe illnesses as meningitis and acute flaccid paralysis. EVs have globally posed a threat to children, and outbreaks of aseptic meningitis and hand, foot and mouth disease are frequently reported. Objective To identify EV strains circulating among healthy children in a small community in Limbe, Cameroon two years apart. Study design Species and EV types were obtained by partial 5′UTR-VP4 and VP1 sequencing of RNA from stool samples collected in October 2009 and September 2011 from 150 children in Cameroon. Results In all, 74 children (49%) were infected with 28 different types of EV. There were 29 (54%) infected children in 2009, and 45 (47%) in 2011. There was a significant difference between detected species of EV, with 15 (47%) children infected with EV-A in 2009, and 22 (71%) with EV-B in 2011 ( p =0.0001). In 2009, one child was infected by a divergent EV, which was most similar to EV-A90. Based on the complete VP1 sequence, it was shown to be a new EV designated EV-A119. Conclusion The current study shows a high heterogeneity of circulating EV types among children in Limbe, Cameroon, and a previously not described shift in predominating EV species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect