Multimodal Diagnostics of Microrheologic Alterations in Blood of Coronary Heart Disease and Diabetic Patients
| Autor: | Petr B. Ermolinskiy, Alexander V. Priezzhev, Alexandra Pigurenko, Yury I. Gurfinkel, M. L. Sasonko, Anastasia I. Maslianitsyna, Andrei E. Lugovtsov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry 030204 cardiovascular system & hematology 01 natural sciences Article laser aggregometry laser tweezers 010309 optics 03 medical and health sciences Human health red blood cell aggregation 0302 clinical medicine In vivo Internal medicine Diabetes mellitus 0103 physical sciences medicine In patient coronary heart disease blood rheology lcsh:R5-920 business.industry Significant difference Type 2 Diabetes Mellitus medicine.disease Coronary heart disease Red blood cell aggregation diabetes mellitus Cardiology lcsh:Medicine (General) business digital capillaroscopy |
| Zdroj: | Diagnostics Volume 11 Issue 1 Diagnostics, Vol 11, Iss 76, p 76 (2021) |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11010076 |
| Popis: | Coronary heart disease (CHD) has serious implications for human health and needs to be diagnosed as early as possible. In this article in vivo and in vitro optical methods are used to study blood properties related to the aggregation of red blood cells in patients with CHD and comorbidities such as type 2 diabetes mellitus (T2DM). The results show not only a significant difference of the aggregation in patients compared to healthy people, but also a correspondence between in vivo and in vitro parameters. Red blood cells aggregate in CHD patients faster and more numerously in particular the aggregation index increases by 20 ± 7%. The presence of T2DM also significantly elevates aggregation in CHD patients. This work demonstrates multimodal diagnostics and monitoring of patients with socially significant pathologies. |
| Databáze: | OpenAIRE |
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