Pediatric lung adenocarcinoma presenting with brain metastasis: a case report
| Autor: | Giuseppe Cinalli, Paolo Muto, Maria Elena Errico, Stefano Chiaravalli, Lucia Quaglietta, Andrea Ferrari, Lucia De Martino, Paola Collini, Serena Ruotolo, Daniele Cascone |
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| Rok vydání: | 2018 |
| Předmět: |
Lung adenocarcinoma
0301 basic medicine Oncology medicine.medical_specialty Lung Neoplasms medicine.medical_treatment lcsh:Medicine Case Report Cancer immunotherapy Adenocarcinoma of Lung TREP 03 medical and health sciences Fatal Outcome 0302 clinical medicine Surgical oncology Internal medicine medicine Humans Child Pathological Lung Brain Neoplasms business.industry Brain metastasis Rare tumor lcsh:R Cancer General Medicine medicine.disease Radiation therapy Nivolumab 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Adenocarcinoma Female business |
| Zdroj: | Journal of Medical Case Reports Journal of Medical Case Reports, Vol 12, Iss 1, Pp 1-8 (2018) |
| ISSN: | 1752-1947 |
| Popis: | Background Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma. Case presentation A 10-year-old white girl presented with brain metastases due to primary pulmonary adenocarcinoma. Next generation sequencing analysis with “Comprehensive Cancer Panel” highlighted the presence of multiple non-targetable mutations in the FLT4, UBR5, ATM, TAF1, and GUCY1A2 genes. She was treated aggressively with chemotherapy, surgery, and radiation therapy for local and distant recurrence. Eventually, therapy with nivolumab was started compassionately, and she died 23 months after diagnosis. Conclusions Extremely rare cancers in children such as lung adenocarcinoma need accurate and specific diagnosis in order to develop an optimal plan of treatment. It is also necessary to underline that “children are not little adults,” thus implying that an adult-type cancer in the pediatric population might have a different etiopathogenesis. Diagnostic confirmation and primary treatment of such rare conditions should be centralized in reference centers, collaborative networks, or both, with multidisciplinary approaches and very specific expertise. |
| Databáze: | OpenAIRE |
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