Comprehensive assessment of unutilized and obsolete pesticides impact on genetic status and health of population of Almaty region

Autor: Elmira Khussainova, Nazym Altynova, Elvira Shadenova, Matthieu Delannoy, Alexander Garshin, Sholpan Bakhtiyarova, Oraz Sapargali, Bakhytzhan Bekmanov, E. D. Djangalina, Stefan Jurjanz, Mukhtar Baizhanov, Leyla Djansugurova, Bolat Zhaksymov, Akerke Seisenbayeva, Unzira Kapysheva
Přispěvatelé: Institute of General Genetics and Cytology, Al-Farabi Kazakh National University [Almaty] (KazNU), Institute of Human and Animal Physiology, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Rok vydání: 2020
Předmět:
Health
Toxicology and Mutagenesis
0211 other engineering and technologies
[SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy
02 engineering and technology
010501 environmental sciences
01 natural sciences
Toxicology
chemistry.chemical_compound
Food chain
Hydrocarbons
Chlorinated
ComputingMilieux_MISCELLANEOUS
2. Zero hunger
education.field_of_study
Dieldrin
[SDE.IE]Environmental Sciences/Environmental Engineering
Aldrin
food and beverages
General Medicine
Pollution
3. Good health
[SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies
Environmental Pollutants
Endosulfan
Hexachlorocyclohexane
Environmental Monitoring
Population
[SDV.SA.ZOO]Life Sciences [q-bio]/Agricultural sciences/Zootechny
[SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain
Biology
[SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study
Animals
Humans
Pesticides
education
0105 earth and related environmental sciences
021110 strategic
defence & security studies
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
business.industry
Public Health
Environmental and Occupational Health
Environmental Exposure
Pesticide
Food safety
chemistry
13. Climate action
Endrin
Cattle
business
Environmental Pollution
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Ecotoxicology and Environmental Safety
Ecotoxicology and Environmental Safety, Elsevier, 2020, 202, pp.110905. ⟨10.1016/j.ecoenv.2020.110905⟩
ISSN: 1090-2414
0147-6513
DOI: 10.1016/j.ecoenv.2020.110905⟩
Popis: The group of persistent organic pollutants (POPs) are particularly dangerous for the environment and by consequence for human health because of the risk to be transmitted in the food chain. Among them, the urgent problem of obsolete and forbidden organochlorinated pesticides (OCPs) needs a rigorous management in many countries, including Kazakhstan. The aim of our study was to evaluate the effect of pesticides content in food products on the genetic status and health of the population living on the contaminated areas near destroyed warehouses for OCPs (4 villages of Talgar district and 1 control site, Almaty region). The food products sampled in Taukaraturyk (control site), and in 4 villages where non-utilized obsolete pesticides were discovered: Beskainar, Kyzylkairat, Amangeldy, and Belbulak. The contents of 24 pesticides in food products from plant (apples, pears, tomatoes, cucumbers, sweet peppers) and animal (beef meat, cow milk, honey) origin, that grown in places of localization of non-utilized OCPs, were determined, sometimes in high and unacceptably high concentrations (before 2500 times over MRL). In pears, the pesticides content (especially DDT, γ-HCH, β-HCH, endosulfan, and aldrin pesticide group), was higher than in other fruits. Among vegetables, the highest levels of all groups of pesticide were found in cucumbers. Beef meat samples demonstrated increased contents of β-HCH, γ-HCH, endrin and dieldrin. In cow milk samples only the high concentration of dieldrin was found. The content of pesticides in meat was 4–5 times higher than in milk. The medical examinations, carried out among the cohorts living around the polluted by pesticides territories and control cohort from ecologically favorable village, showed that there were more individuals with high and middle levels of somatic health in the control group than in groups exposed to OCPs. The long-term effect of the pesticide contamination of the environment on genetic status of the population was assessed by chromosomal aberration (CA) frequencies. The highest level of chromosomal aberrations was identified for the examined residents of Kyzylkairat (41%) and Belbulak (38%), a high level in Amangeldy (12%), and middle level in Beskainar (6.5%). The association between the CA frequency, health status and the pesticides contents in food were assessed by a Spearman rank correlation. The low indicators of somatic health status were strictly associated with high levels of CA, and good health status indicates that the CA rates did not exceed the spontaneous level of mutagenesis. The strongest correlation was shown between high levels of chromosomal aberrations and the content of different pesticides in pears (Cr = 0.979–0.467), tomatoes (Cr = 0.877–0.476), cucumbers (Cr = 0.975–0.553) and meat (Cr = 0.839–0.368). The obtained results highlight the need to improve health protection by increasing the public awareness to the security of the storage of obsolete OCPs in order to strengthen food safety by efficient control services.
Databáze: OpenAIRE
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