β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly
| Autor: | Oskar Hansson, Niklas Mattsson, Erik Stomrud, Philip S. Insel, Anna L. Svenningsson, Sebastian Palmqvist |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Aging Neurology lcsh:Medicine Hippocampus Cohort Studies Cognition 0302 clinical medicine Cerebrospinal fluid Medicine Cognitive decline lcsh:Science Aged 80 and over Cerebral Cortex Multidisciplinary medicine.diagnostic_test Cognitive ageing Neurodegeneration Age Factors Alzheimer's disease Magnetic Resonance Imaging Healthy Volunteers Female medicine.medical_specialty tau Proteins Article 03 medical and health sciences Atrophy Memory Internal medicine Humans Chitinase-3-Like Protein 1 Neuroinflammation Aged Memory Disorders Amyloid beta-Peptides business.industry lcsh:R Magnetic resonance imaging medicine.disease Peptide Fragments Cross-Sectional Studies 030104 developmental biology Endocrinology lcsh:Q business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-47638-y |
| Popis: | The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of cerebrospinal fluid biomarkers for amyloid-β (Aβ42/40), neuroinflammation (YKL-40), and neurodegeneration and tau pathology (T-tau and P-tau) as well as MRI measures of white-matter lesions, hippocampal volume (HV), and regional cortical thickness. We found that Aβ positivity and HV were independently associated with memory. Results differed depending on age, with memory being associated with HV (but not Aβ) in older participants (73.3–88.4 years), and with Aβ (but not HV) in relatively younger participants (65.2–73.2 years). This indicates that Aβ and atrophy are independent contributors to memory variability in cognitively healthy elderly and that Aβ mainly affects memory in younger elderly individuals. With advancing age, the effect of brain atrophy overshadows the effect of Aβ on memory function. |
| Databáze: | OpenAIRE |
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