The Current Role of the Heavy/Light Chain Assay in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma: An Evidence-Based Approach

Autor: Macarena Algarín, Nuno Barbosa, Noemi Puig, José Luis García de Veas Silva, Bruno Paiva, José Ángel Hernández, Cristina Encinas, J. Martínez-López, Rafael Alberto Alonso, Teresa Rodríguez, Alberto Leivas, Rafael Ríos-Tamayo, Maria Luisa Campos, Juan José Lahuerta, María José Olivares, María José Sánchez
Rok vydání: 2021
Předmět:
Zdroj: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Diagnostics, Vol 11, Iss 2020, p 2020 (2021)
Diagnostics
Digital.CSIC. Repositorio Institucional del CSIC
ISSN: 2075-4418
DOI: 10.3390/diagnostics11112020
Popis: © 2021 by the authors.
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM.
Databáze: OpenAIRE
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