Recreational scuba diving: negative or positive effects of oxidative and cardiovascular stress?
| Autor: | Antonija Perović, Adriana Unić, Jerka Dumić |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
diving
Cell signaling Antioxidant medicine.medical_treatment Clinical Biochemistry Review Oxidative phosphorylation Biology medicine.disease_cause Cardiovascular System Antioxidants BIOMEDICINE AND HEALTHCARE. Pharmacy. Medical Biochemistry sirtuins oxidative stress cardiovascular system medicine Humans BIOMEDICINA I ZDRAVSTVO. Farmacija. Medicinska biokemija Regulation of gene expression chemistry.chemical_classification Reactive oxygen species Biochemistry (medical) Forkhead Transcription Factors Adaptation Physiological Cell biology Scuba diving Oxidative Stress Gene Expression Regulation Biochemistry chemistry Tumor Suppressor Protein p53 Signal transduction Reactive Oxygen Species Oxidation-Reduction human activities Oxidative stress Signal Transduction |
| Zdroj: | Biochemia Medica Volume 24 Issue 2 |
| ISSN: | 1846-7482 1330-0962 |
| Popis: | Environmental conditions and increased physical activity during scuba diving are followed by increased production of free radicals and disturbed redox balance. Redox balance disorder is associated with damage of cellular components, changes of cellular signaling pathways and alterations of gene expression. Oxidative stress leads to increased expression of sirtuins (SIRTs), molecules which play an important role in the antioxidant defense, due to their sensitivity to the changes in the redox status and their ability to regulate redox homeostasis. These facts make SIRTs interesting to be considered as molecules affected by scuba diving and in that sense, as potential biomarkers of oxidative status or possible drug targets in reduction of reactive oxygen species (ROS) accumulation. In addition, SIRTs effects through currently known targets make them intriguing molecules which can act positively on health in general and whose expression can be induced by scuba diving. A demanding physical activity, as well as other circumstances present in scuba diving, has the greatest load on the cardiovascular function (CV). The mechanisms of CV response during scuba diving are still unclear, but diving-induced oxidative stress and the increase in SIRTs expression could be an important factor in CV adaptation. This review summarizes current knowledge on scuba diving-induced oxidative and CV stress and describes the important roles of SIRTs in the (patho)physiological processes caused by the redox balance disorder. |
| Databáze: | OpenAIRE |
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