Role of corticotropin-releasing factor on bladder function in rats with psychological stress

Autor: Hideaki Ito, Yoshitaka Aoki, Minekatsu Taga, So Inamura, X-M. Zha, Masaya Seki, Osamu Yokoyama, Yosuke Matsuta
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Contraction (grammar)
Corticotropin-Releasing Hormone
lcsh:Medicine
medicine.disease_cause
urologic and male genital diseases
Rats
Sprague-Dawley
0302 clinical medicine
Muscarinic acetylcholine receptor
Psychological stress
Antalarmin
lcsh:Science
media_common
Multidisciplinary
Peripheral
Bladder function
Injections
Intraperitoneal
hormones
hormone substitutes
and hormone antagonists
medicine.drug
medicine.medical_specialty
endocrine system
Urology
media_common.quotation_subject
Bladder
Urinary Bladder
Urination
Neurophysiology
Receptors
Corticotropin-Releasing Hormone
Article
Peptide hormones
03 medical and health sciences
Internal medicine
medicine
Animals
Pyrroles
Receptor
Muscarinic M3
Receptor
Muscarinic M2
business.industry
lcsh:R
Antagonist
Rats
Disease Models
Animal
030104 developmental biology
Endocrinology
Pyrimidines
Case-Control Studies
lcsh:Q
business
030217 neurology & neurosurgery
Stress
Psychological
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-019-46267-9
Popis: Stress-related peptide corticotropin-releasing factor (CRF) and CRF-related peptides are distributed in the peripheral viscera such as the bladder. We investigated the contribution of psychological stress (PS) and CRF on bladder function. Male rats received sham stress (SS) or PS using a communication box method for 120 min every day for 7 days. One group of rats received the intraperitoneal CRF-R1 antagonist antalarmin for 7 days during stress exposure. Mean voided volume per micturition was significantly lower in PS rats compared to SS rats, which was antagonized by antalarmin treatment. Increases in plasma and bladder CRF, and mRNA expressions of bladder CRF, CRF-R1, and M2/3 muscarinic receptors, were found in PS rats. CRF did not influence bladder contraction in itself; however, stress increased the response of muscarinic contraction of bladder strips. These changes were antagonized by antalarmin treatment. In conclusion, PS reinforces M3 receptor-mediated contractions via CRF-R1, resulting in bladder storage dysfunction.
Databáze: OpenAIRE
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