Oxidative stress parameters in children with acute rheumatic fever
| Autor: | Ömer Alyan, Fatma Birgul Isik, Ayfer Gozu Pirinccioglu, Göksel Kızıl, Alper Akın |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Matched-Pair Analysis medicine.medical_treatment Disease 030204 cardiovascular system & hematology Protein oxidation medicine.disease_cause Gastroenterology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030225 pediatrics Internal medicine Humans Medicine Prospective Studies Child business.industry Acute rheumatic fever Malondialdehyde Oxidative Stress Cytokine chemistry Case-Control Studies Pediatrics Perinatology and Child Health Disease Progression Cytokines Female Tumor necrosis factor alpha Rheumatic Fever business Biomarkers Oxidative stress |
| Zdroj: | Pediatrics International. 61:962-966 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/ped.13983 |
| Popis: | BACKGROUND The aim of this study was to investigate of the role of oxidative stress (OS) in acute rheumatic fever (ARF) and its relationship with the progress of the disease. METHODS Thirty patients with ARF and 31 age-sex-matched healthy children were enrolled in this study. Serum malondialdehyde (MDA), protein carbonyl (PCO), high-sensitivity C-reactive protein (hs-CRP), cytokines (tumor necrosis factor-α and interleukin-6) and total antioxidant capacity (TAC) were measured. The diagnosis of ARF was based on the Jones criteria. RESULTS Patients with ARF had significantly higher serum MDA, PCO, hs-CRP and cytokine levels and lower TAC than healthy controls. On Pearson's correlation analysis we found that oxidative stress markers were positively correlated with hs-CRP and cytokines, while TAC was negatively correlated with MDA, PCO, hs-CRP and cytokines. The number of valves involved as well as the level of mitral valve involvement was also significantly related to the oxidative stress parameters and TAC. All oxidative stress parameters decreased significantly with anti-inflammatory therapy while TAC increased. CONCLUSION Malondialdehyde and PCO, as biomarkers, as well as hs-CRP together with the other available diagnostic tools, can be used in the evaluation of patients with ARF. |
| Databáze: | OpenAIRE |
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