Dermal absorption and hydrolysis of methylparaben in different vehicles through intact and damaged skin: using a pig-ear model in vitro
| Autor: | Jarmila Hojerová, Silvia Pažoureková, Zuzana Klimová, Marianna Lucová |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Skin Absorption Sus scrofa Parabens In Vitro Techniques Toxicology Administration Cutaneous Hydrogel Polyethylene Glycol Dimethacrylate chemistry.chemical_compound Stratum corneum medicine Animals Humans Ethylparaben Biotransformation Skin Butylparaben Cryopreservation Chromatography Methylparaben Preservatives Pharmaceutical Ear General Medicine Metabolism In vitro medicine.anatomical_structure chemistry Urea Emulsions Female Dermatologic Agents Pharmaceutical Vehicles Hydrophobic and Hydrophilic Interactions Propylparaben Abattoirs Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 59 |
| ISSN: | 1873-6351 |
| Popis: | Currently, there is a trend to reduce of parabens use due to concern about the safety of their unmetabolised forms. This paper focused on dermal absorption rate and effectiveness of first-pass biotransformation of methylparaben (MP) under in-use conditions of skincare products. 24-h exposure of previously frozen intact and tapestripped (20 strips) pig-ear skin to nine vehicles containing 0.1% MP (AD, applied dose of 10 μg/cm²), resulted in 2.0-5.8%AD and 2.9-7.6%AD of unmetabolised MP, and 37.0-73.0%AD and 56.0-95.0%AD of p-hydroxybenzoic acid, respectively, in the receptor fluid. The absorption rate of MP was higher from emulsions than from hydrogels, from enhancer-containing vehicles than from enhancer-free vehicles, and when skin was damaged. Experiments confirmed that the freezing of pig-ear skin slightly reduces hydrolysis of MP. After 4-h exposure of intact freshly excised and intact frozen stored skin, amount of |
| Databáze: | OpenAIRE |
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