The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris
| Autor: | Mehrali Rahimi, Asad Vaisi-Raygani, Fariba Najafi, Fariborz Bahrehmand, Ali Ebrahimi, Ziba Rahimi, Sakineh Zinati-Saeed, Ebrahim Shakiba, Mona Akbari, Zohreh Rahimi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
insulin medicine.medical_treatment Reductase 030207 dermatology & venereal diseases 03 medical and health sciences Insulin-like growth factor 0302 clinical medicine Insulin resistance Polymorphism (computer science) Internal medicine Genotype medicine Pathology RB1-214 Acne vulgaris Allele biology business.industry Insulin Methylenetetrahydrofolate reductase Homeostasis model assessment medicine.disease Endocrinology Insulin-like growth factor-1 030220 oncology & carcinogenesis biology.protein Original Article business |
| Zdroj: | Iranian Journal of Pathology Iranian Journal of Pathology, Vol 15, Iss 1, Pp 23-29 (2020) |
| ISSN: | 2345-3656 1735-5303 |
| Popis: | Background & Objective: To find an association between gene variants of insulin-like growth factor-1 (IGF-1) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with the risk of acne vulgaris (AV). Methods: In a case-control study, we investigated 150 AV patients and 148 healthy individuals (aged 18-25 years) for the IGF-1 G>A and MTHFR C677T polymorphisms, as well as the serum levels of IGF-1, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR). The serum biochemical parameters and the genotypes of IGF-1 G>A and MTHFR C677T were detected by using appropriate kits and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods, respectively. Results: The frequencies of IGF-1 and the MTHFR polymorphisms were not significantly different comparing patients and controls. The serum level of IGF-1 was 179.8±72.8 µg/L in AV patients compared to 164.6±63.7 µg/L in controls (P=0.056). The serum level of insulin in female patients was significantly higher than controls. The HOMA was 3.54±5.6 in patients compared to 1.16±1.4 (P |
| Databáze: | OpenAIRE |
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