Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine
| Autor: | Katherine S. Lee, Jennifer Canniff, Aneesh K. Mehta, Nadine Rouphael, Myron J. Levin, Guang-Yun Cai, Mark J. Mulligan, Adriana Weinberg |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Herpesvirus 3 Human Herpes Zoster Vaccine viruses T-Lymphocytes Viremia Antibodies Viral Vaccines Attenuated Herpes Zoster Virus law.invention 03 medical and health sciences Major Articles and Brief Reports 0302 clinical medicine Immune system Immunity law medicine Immunology and Allergy Humans 030212 general & internal medicine Polymerase chain reaction biology integumentary system business.industry virus diseases biochemical phenomena metabolism and nutrition medicine.disease Virology 030104 developmental biology Infectious Diseases DNA Viral biology.protein Zoster vaccine Antibody business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 217(7) |
| ISSN: | 1537-6613 |
| Popis: | We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. |
| Databáze: | OpenAIRE |
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