| Autor: |
Jana Slováková, Mateusz Sikora, Feyza Nur Arslan, Silvia Caballero-Mancebo, S. F. Gabriel Krens, Walter A. Kaufmann, Jack Merrin, Carl-Philipp Heisenberg |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 119(8) |
| ISSN: |
1091-6490 |
| Popis: |
Significance Cell–cell contact formation is a key step in the evolution of multicellularity. While the molecular and cellular processes underlying cell–cell adhesion and contact formation have been extensively studied, comparably little is known about the physical principles guiding these processes. Actomyosin cortex tension differentially applied at the cell–cell and cell–medium interfaces was shown to promote expansion of the cell–cell contacts. Here, we uncover a nonlinear relationship between cortex tension and cell–cell contact size; in a low-tension regime, cell–cell contact size positively scales with cortex tension, while the high-tension regime promotes small contacts. This change in behavior is due to tension decreasing the turnover of adhesion molecules at the cell–cell contact, limiting contact expansion. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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