Immunoreactive β-Endorphin and Pro-γ-Melanotropin in the Peripheral Circulation during the Menstrual Cycle
| Autor: | P.C. Owens, Margaret Lovelock, Eng-Cheng Chan, Roger Smith, Paul Martyn |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pro-Opiomelanocortin Melanocyte-stimulating hormone media_common.quotation_subject Ovary Biology chemistry.chemical_compound Internal medicine medicine Humans Secretion Melanocyte-Stimulating Hormones Opioid peptide Menstrual Cycle Menstrual cycle media_common beta-Endorphin Obstetrics and Gynecology Peptide Fragments Glycopeptide Endocrinology medicine.anatomical_structure chemistry Female hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Asia-Oceania Journal of Obstetrics and Gynaecology. 13:345-350 |
| ISSN: | 0389-2328 |
| Popis: | The ovary contains β-endorphin but it is not clear whether it secretes this opioid peptide in amounts sufficient to increase β-endorphin concentrations in the peripheral circulation, and hence effect β-endorphin-sensitive mechanisms controlling hypo-thalamic secretion of gonadotropin-releasing hormone and pituitary secretion of gonadotrophins. To examine the possible ovarian contribution to the circulating pool of β-endorphin and related peptides we measured the plasma concentrations of immunoreactive β-endorphin and the cosynthesized glycopeptide, pro-γ-melanotropin, in different phases of a normal menstrual cycle. Ovarian steroids and pituitary gonadotrophins showed the expected cyclical changes. Plasma cortisol, immunoreactive β-endorphin and immunoreactive pro-γ-melanotropin concentrations were not significantly different in different phases of the cycle. There was no discernible relationship between plasma concentrations of either immunoreactive β-endorphin or pro-γ-melanotropin and any of oestradiol, progesterone, luteinising hormone and follicle-stimulating hormone overall or during any phase of the menstrual cycle. The results suggest that the ovary does not contribute significantly to the pool of β-endorphin and related peptides in circulating blood. |
| Databáze: | OpenAIRE |
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