Aversive olfactory associative memory loses odor specificity over time
| Autor: | Ayse Yarali, Archana Durairaja, Vignesh Viswanathan, Anne Voigt, Mathangi Ganesan, Kasyoka Kilonzo, Christian König, Emmanuel Antwi-Adjei |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Time Factors Physiology Short Communication Conditioning Classical education Generalization Olfaction Aquatic Science Long-term memory 03 medical and health sciences 0302 clinical medicine Memory Avoidance learning Generalization (learning) Avoidance Learning Animals Molecular Biology Ecology Evolution Behavior and Systematics Communication Post-traumatic stress disorder Behavior Animal business.industry Aversive associative memory Association Learning PTSD Content-addressable memory Smell Drosophila melanogaster 030104 developmental biology Odor Insect Science Odorants Female Animal Science and Zoology business Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The journal of experimental biology, 220: 1548-1553 The Journal of Experimental Biology |
| ISSN: | 1477-9145 0022-0949 |
| Popis: | Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor–electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder. Highlighted Article: Associative memories of noxious experiences can become detrimental if overly generalized; fruit fly aversive memories lose their specificity over time, mimicking the situation in rodents and humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|