Clinical course and long-term outcome of hantavirus-associated nephropathia epidemica, Germany
| Autor: | Evelina Tacconelli, Joerg Latus, Albrecht Wiedenmann, Barbara Mezger, Stephan Segerer, Daniel Wegener, David Zakim, Martin Priwitzer, Niko Braun, Stefan O Brockmann, Birgit Walter-Frank, Matthias Schwab, M. Dominik Alscher, Angela Corea, Simon Müller, Daniel Kitterer, Friedrich-Michael Pieper, Christoph Pöhlmann, Juergen Dippon |
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| Přispěvatelé: | University of Zurich, Braun, Niko |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Epidemiology animal diseases viruses lcsh:Medicine Disease urologic and male genital diseases Gastroenterology Puumala virus 2726 Microbiology (medical) Germany Nephropathia epidemica Medicine 10035 Clinic for Nephrology Prospective Studies Prospective cohort study Proteinuria biology Acute kidney injury virus diseases nephropathia epidemica Middle Aged female genital diseases and pregnancy complications Infectious Diseases acute kidney injury Adult Cross-Sectional Studies Female Hematuria Hemorrhagic Fever with Renal Syndrome Humans Hypertension medicine.symptom Hantavirus Microbiology (medical) long-term outcome medicine.medical_specialty 610 Medicine & health Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica Germany epidemic nephropathy lcsh:Infectious and parasitic diseases Internal medicine PUUV lcsh:RC109-216 business.industry Research lcsh:R 2725 Infectious Diseases medicine.disease biology.organism_classification Humoral immunity Immunology proteinuria business 2713 Epidemiology |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 21, Iss 1, Pp 76-83 (2015) |
| Popis: | The consequences of associated hematuria may be long-lasting, and hantavirus IgG is detectable years after acute infection. Human infection with Puumala virus (PUUV), the most common hantavirus in Central Europe, causes nephropathia epidemica (NE), a disease characterized by acute kidney injury and thrombocytopenia. To determine the clinical phenotype of hantavirus-infected patients and their long-term outcome and humoral immunity to PUUV, we conducted a cross-sectional prospective survey of 456 patients in Germany with clinically and serologically confirmed hantavirus-associated NE during 2001–2012. Prominent clinical findings during acute NE were fever and back/limb pain, and 88% of the patients had acute kidney injury. At follow-up (7–35 mo), all patients had detectable hantavirus-specific IgG; 8.5% had persistent IgM; 25% had hematuria; 23% had hypertension (new diagnosis for 67%); and 7% had proteinuria. NE-associated hypertension and proteinuria do not appear to have long-term consequences, but NE-associated hematuria may. All patients in this study had hantavirus-specific IgG up to years after the infection. |
| Databáze: | OpenAIRE |
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