International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I)
| Autor: | Janine A. Clayton, Hasanain Shikari, Anjo Riemens, Reza Dana, Stella K. Kim, Sandeep Jain, Mark I. Rosenblatt, Kazuo Tsubota, Victor L. Perez, Yoko Ogawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Consensus medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Eye Article Young Adult immune system diseases Internal medicine Medicine Humans Young adult Host disease Multidisciplinary business.industry Hematopoietic Stem Cell Transplantation eye diseases Surgery Clinical research Chronic disease surgical procedures operative Chronic Disease Chronic gvhd Christian ministry Female business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity. |
| Databáze: | OpenAIRE |
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