Endothelin‐1 levels are decreased in pediatric Type 1 diabetes and negatively correlate with the carotid intima media thickness
| Autor: | Naim Shehadeh, Mogher Khamaisi, Smadar Shilo, Michal Cohen, Anat Ilivitzki, Raya Gendelman, Hiba Yaseen, Ram Weiss, Nehama Zuckerman-Levin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Carotid Intima-Media Thickness Exercise time Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Child Reactive hyperemia Type 1 diabetes Endothelin-1 business.industry Mean age medicine.disease Endothelin 1 Diabetes Mellitus Type 1 Intima-media thickness Case-Control Studies Pediatrics Perinatology and Child Health Cardiology Female business Pediatric population |
| Zdroj: | Pediatric Diabetes. 22:916-923 |
| ISSN: | 1399-5448 1399-543X |
| DOI: | 10.1111/pedi.13237 |
| Popis: | AIMS Better understanding of the timeline and risk factors for the appearance of complications in pediatric Type-1-diabetes is key for developing prevention strategies. We studied endothelial markers and their determinants in adolescents with Type-1-diabetes at different time points from diagnosis. METHODS A cross-sectional study of 58 adolescents, mean age 15.0 ± 2.4 years; 20 with recent-onset Type-1-diabetes, 20 with over 7 years of Type-1-diabetes and 18 controls. Clinical and biochemical data were collected. Fingertip arterial reactive hyperemia (EndoPAT) and carotid intima-media-thickness (cIMT) were measured to assess endothelial function and structure. RESULTS Compared to controls, individuals with prolonged Type-1-diabetes had higher mean cIMT (0.49 ± 0.07 mm vs. 0.43 ± 0.05 mm p = 0.021) and maximal cIMT (0.61 ± 0.08 mm 0.52 ± 0.08 mm, p = 0.025). Endothelin-1 levels were significantly lower in subjects with prolonged Type-1-diabetes (1.2 ± 1.0 pg/ml) compared to controls (3.0 ± 1.7, p = 0.008 pg/ml); they negatively correlated with the mean cIMT (c = - 0.291, p = 0.031) and mean 6 months hemoglobin A1c (c = - 0.301, p = 0.022) and positively correlated with mean c-peptide levels (c = 0.356, p = 0.006) and the weekly exercise time (c = 0.485, p |
| Databáze: | OpenAIRE |
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