Two decades of pediatric celiac disease in a tertiary referral center: What has changed?
| Autor: | Raanan Shamir, Yael Mozer-Glassberg, Luba Marderfeld, Noam Zevit, Anat Guz-Mark, Ari Silbermintz, Orith Waisbourd-Zinman, Michal Rozenfeld Bar Lev, Amit Assa, Vered Nachmias Friedler, Alexander Krauthammer, Manar Matar |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Disease Risk Assessment Severity of Illness Index Serology Tertiary Care Centers Diet Gluten-Free 03 medical and health sciences 0302 clinical medicine Weight loss Chart review Epidemiology medicine Humans Israel Child Retrospective Studies Hepatology business.industry Gastroenterology Abdominal Pain Celiac Disease Treatment Outcome Child Preschool 030220 oncology & carcinogenesis Cohort Patient Compliance Referral center Female 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Digestive and Liver Disease. 52:457-461 |
| ISSN: | 1590-8658 |
| DOI: | 10.1016/j.dld.2020.02.001 |
| Popis: | Celiac disease (CD) is common worldwide with increasing prevalence and changing presentation.To evaluate changes in the presentation and management of CD over the last two decades.Retrospective chart review of pediatric patients with CD between 01.1999 to 12.2018 was performed. Comparisons were made between an early (1999 to 2008) and late (2009 to 2018) decade, regarding clinical and laboratory parameters at presentation and follow-up.In a cohort of 932 patients (early decade n = 316, late decade n = 616), patients from the late decade presented with lower rates of weight loss and abdominal distention (24.2% vs 34.7% and 6% vs 11%, respectively p 0.01), and with higher rates of abdominal pain or asymptomatic presentation (41.4% vs 27.4%, p 0.01, and 18% vs 13%, p 0.05, respectively). Good adherence to gluten-free diet was reported more often in the late decade (64% vs 50.6%, p 0.001), and fewer patients were lost to follow-up. During the late decade, significantly higher rates of celiac serology normalization were achieved during the first two years of follow-up.In recent years, children with CD were diagnosed with milder symptoms, showed better adherence and demonstrated earlier normalization of celiac serology. |
| Databáze: | OpenAIRE |
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