Codonopsis lanceolata extract prevents hypertension in rats
| Autor: | Hui Su Lee, Young Seok Lee, Kwang Won Lee, Soonho Kwon, Geun Hee Seol, A. Young Han |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Neutrophils Pharmaceutical Science Blood lipids Blood Pressure Vasodilation Pharmacology Rats Sprague-Dawley Nicotine 03 medical and health sciences Nifedipine Heart Rate Drug Discovery Heart rate Animals Medicine Codonopsis lanceolata Antihypertensive Agents Codonopsis Plants Medicinal Ethanol biology Plant Extracts business.industry biology.organism_classification 030104 developmental biology Blood pressure Complementary and alternative medicine Vasoconstriction Hypertension Molecular Medicine medicine.symptom business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | Phytomedicine. 39:119-124 |
| ISSN: | 0944-7113 |
| DOI: | 10.1016/j.phymed.2017.12.028 |
| Popis: | Background Codonopsis lanceolata, a plant with antioxidant, anti-cancer, anti-inflammatory and blood lipid improving effects, has been widely used as a therapeutic agent in traditional medicine. Purpose The present study investigated the ability of an ethanol extract of Codonopsis lanceolata (ECL) to prevent hypertension in hypertensive rats. Methods Rats were orally administered daily doses of 0 mg/kg, 200 mg/kg and 400 mg/kg ECL for 3 weeks. As a positive control, rats were orally administered 10 mg/kg/day nifedipine. Hypertension was induced by immobilization stress for 2 h/day and by administration of 0.8 mg/kg/day nicotine for 3 weeks, followed by injection of 3 mg/kg nicotine on the day of sacrifice. Blood pressure and heart rate were measured using a volume pressure recording system. Vasoconstriction and vasodilation of aortic cross sections were measured with a physiological recorder. Neutrophil counts in bronchoalveolar lavage fluid were estimated with an automated cell counter. Results Treatment with both dosages of ECL significantly reduced systolic blood pressure (SBP) in hypertensive rats. Both doses of ECL tended to increase ACh- and SNP-induced vascular relaxation in hypertensive rats. Treatment with 200 mg/kg ECL significantly reduced neutrophil in hypertensive rats. Conclusions These results suggest that ECL is effective in reducing SBP and inflammation in hypertensive conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect